Kin17在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2023.03.013

实用肿瘤学杂志 ›› 2023, Vol. 37 ›› Issue (3): 272-275.doi: 10.11904/j.issn.1002-3070.2023.03.013

Kin17在肿瘤中的研究进展

钟学进¹, 吴春梅², 李秋燕² 综述, 曾涛² 审校

1.广东医科大学附属第二医院检验医学科(湛江 524003);
2.广东医科大学附属医院检验科

收稿日期:2023-03-12 修回日期:2023-05-10 出版日期:2023-06-28 发布日期:2023-08-07
通讯作者: 曾涛,E-mail:zengt@smu.edu.cn
作者简介:钟学进,男,(1992-),硕士,主管技师,从事肿瘤标志物的研究。

Research progress of Kin 17 in tumors

ZHONG Xuejin¹, WU Chunmei², LI Qiuyan², ZENG Tao²

1. Department of Medical laboratory,The Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524003,China;
2. Department of Clinical Laboratory,Affiliated Hospital of Guangdong Medical University

Received:2023-03-12 Revised:2023-05-10 Online:2023-06-28 Published:2023-08-07

摘要/Abstract

摘要： 核蛋白17(Nuclear immunological kinship to rec A protein,Kin17)是一种DNA或RNA结合蛋白,在损伤修复、表观遗传、机体发育和癌变中发挥关键作用。近年来,Kin17在肿瘤中的作用日益受到关注。本文对Kin17的结构、功能和在肿瘤中的研究进展进行综述。

关键词: 核蛋白17, 功能, 肿瘤

Abstract: Nuclear immunological kinship to rec A protein(Kin17)is a DNA or RNA binding protein,which plays a key role in damage repair,epigenetics,body development and carcinogenesis.In recent years,the role of Kin17 in tumors has received increasing attention.This article reviews the structure,function and research progress of Kin17 in tumors.

Key words: Nuclear immunological kinship to rec A protein, Function, Tumor

中图分类号:

R730.2

钟学进, 吴春梅, 李秋燕, 曾涛. Kin17在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(3): 272-275.

ZHONG Xuejin, WU Chunmei, LI Qiuyan, ZENG Tao. Research progress of Kin 17 in tumors[J]. Journal of Practical Oncology, 2023, 37(3): 272-275.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2023.03.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I3/272

参考文献

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
2 Biard DS,Miccoli L,Despras E,et al.Lonizing radiation triggers chromatin-bound Kin17 complex formation in human cells[J].J Biol Chem,2002,277(21):19156-19165.
3 Pattaro Júnior JR,Caruso íP,de Lima Neto QA,et al.Biophysical characterization and molecular phylogeny of human kin protein[J].European Biophysics Journal,2019,48(7):645-657.
4 Mazin A,Milot E,Devoret R,et al.Kin17,a mouse nuclear protein,binds to bent DNA fragments that are found at illegitimate recombination junctions in mammalian cells[J].Mol Gen Genet,1994,244:435-438.
5 Carlier L,Couprie J,le Maire A,et al.Solution structure of the region 51-160 of human Kin17 reveals an atypical winged helix domain[J].Protein Sci,2007,16(12):2750-2755.
6 Kannouche P,Mauffrey P,Pinon-Lataillade G,et al.Molecular cloning and characterization of the human Kin17 cDNA encoding a component of the UVC response that is conserve damongment azoans[J].Carcinogenesis,2000,21:1701-1710.
7 le Maire A,Schiltz M,Stura EA,et al.A tandem of sh3-like domains participates in rna binding in Kin17,a human protein activated in response to genotoxics[J].J Mol Biol,2006,364(4):764-776.
8 Ramos AC,Gaspar VP,Kelmer SM,et al.The Kin17 protein in murine melanoma cells[J].Int J Mol Sci,2015,16(11):27912-27920.
9 Kannouche P,Pinon Lataillade G,Tissier A,et al.The nuclear concentration of Kin17,a mouse protein that binds to curved DNA,increases during cell proliferation and after UV irradiation[J].Carcinogenesis,1998,19(5):781-789.
10 Tissier A,Kannouche P,Mauffrey P,et al.Molecular cloning and characterization of the mouse Kin17 gene coding for a Zn-finger protein that preferentially recognizes bent DNA[J].Genomics,1996,38(2):238-242.
11 Despras E,Miccoli L,Créminon C,et al.Depletion of Kin17,a human DNA replication protein,increases the radiosensitivity of rko cells[J].Radiation Research,2003,159(6):748-758.
12 Miccoli L,Frouin I,Novac O,et al.The human stress activated protein Kin17 belongs to the multiprotein DNA replication complex and associates in vivowith mammalian replication origins[J].Mol Cell Biol,2005,25(9):3814-3830.
13 Cloutier P,Lavallee-Adam M,Faubert D,et al.Methylation of the DNA/rna-binding protein Kin17 by mettl22 affects its association with chromatin[J].J Proteomics,2014,100:115-124.
14 Willkinson L,Toral G.Understanding breast cancer as a global health concern[J].Br J Radiol,2022,95(1130):20211033.
15 Zeng T,Gao H,Yu P,et al.Up-regulation of Kin17 is essential for proliferation of breast cancer[J].PLoS One,2011,6(9):e25343.
16 Huang Q,Zahid KR,Chen J,et al.Kin17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer[J].Thorac Cancer,2021,12(13):2013-2023.
17 Qiu J,Xue X,Hu C,et al.Comparison of clinicopathological features and prognosis in triple-negative and non-triple negative breast cancer[J].J Cancer,2016,7(2):167-173.
18 Gao X,Liu Z,Zhong M,et al.Knockdown of DNA/RNA-binding protein Kin17 promotes apoptosis of triple-negative breast cancer cells[J].Oncology Letters,2018,17:288-293.
19 Zhang Y,Gao H,Gao X,et al.Elevated expression of Kin17 in cervical cancer and its association with cancer cell proliferation and invasion[J].Int J Gynecol Cancer,2017,27(4):628-633.
20 Uxa S,Castillo P,Kohler R,et al.Ki-67 gene expression[J].Cell DeathDiffer,2021,28(12):3357-3370.
21 Zhong M,Liu Z,Wu K,et al.Kin17 knockdown suppresses the migration and invasion of cervical cancer cells through NF-κB-Snail pathway[J].Int J Clin Exp Pathol,2020,13(3):607-615.
22 Su B,Zhong M,Zhang Y,et al.Deficiency of Kin17 facilitates apoptosis of cervical cancer cells by modulating caspase 3,PARP,and Bcl-2 family proteins[J].J Oncol,2022,2022:3156968.
23 Marques LS,Violin VGA,Meireles LEF,et al.Kin17 high expression as a potential biomarker for high-grade cervical intraepithelial neoplasia[J].Int J Gynaecol Obstet,2023,160:339-341.
24 Kou WZ,Xu SL,Wang Y,et al.Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo[J].Oncol Lett,2014,8:1190-1194.
25 Dai Z,Huang Q,Huang X,et al.Kin17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular Carcinoma[J].Mol Carcinog,2023,62:369-384.
26 Yang J,Zhang Y,Sun X,et al.The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants:a SEER-based study[J].J Cancer Res Clin Oncol,2018,144(9):1835-1842.
27 曾涛,陆光明.Kin17在28例肺癌标本中的表达分析[J].检验医学与临床,2013,10(12):1619-1620.
28 Zhang Y,Huang S,Gao H,et al.Upregulation of Kin17 is associated with non-small cell lung cancer invasiveness[J].Oncol Lett,2017,13:2274-2280.
29 吕俊宏,彭盘俐,韦文姜,等.Kin17 在非小细胞肺癌侵袭转移中的作用及机制研究[J].现代生物医学进展,2020,20(15):2838-2842.
30 Chen J,Xia Y,Peng Y,et al.Analysis of the association between Kin17 expression and the clinical features/prognosis of epithelial ovarian cancer,and the effects of Kin17 in SKOV3 cells[J].Oncol Lett,2021,21:475.
31 Jiang QG,Xiong CF,Lv YX.Kin17 facilitates thyroid cancer cell proliferation,migration,and invasion by activating p38 MAPK signaling Pathway[J].Mol Cell Biochem,2021,476:727-739.
32 Ruan L,Jiang Q,Zhang H.Relationships of Kin17 protein expression with clinical features and prognosis of colorectal cancer[J].Transl Cancer Res,2018,7(4):1072-1078.

[1]	周波蓉, 宋雅楠, 夏伟. 吡咯啉-5-羧酸还原酶-1在肿瘤中的作用及机制研究进展[J]. 实用肿瘤学杂志, 2023, 37(3): 267-271.
[2]	殷鼎威, 井杰. 肠道菌群在肝细胞癌中的作用及治疗应用的研究进展[J]. 实用肿瘤学杂志, 2023, 37(3): 281-286.
[3]	刘欣欣, 马西元, 缪美琪, 王语晴, 陈晶. IL-6及其受体在乳腺癌治疗中的作用研究进展[J]. 实用肿瘤学杂志, 2023, 37(2): 149-154.
[4]	杨建华, 罗赛美, 龙欣甜, 李蔚, 杨璧榕, 余龙涛, 张腾, 文洪梅. 2017年云南省肿瘤登记地区恶性肿瘤发病与死亡分析[J]. 实用肿瘤学杂志, 2023, 37(1): 6-10.
[5]	马骥雄, 马菊红, 周红, 鲁朝霞, 丁高恒, 刘玉琴. 2018年甘肃省白银市恶性肿瘤发病和死亡分析[J]. 实用肿瘤学杂志, 2023, 37(1): 11-16.
[6]	蔡圻锐, 于晓兰, 刘家仁. 香叶醇抗肿瘤活性及其他生物学作用的研究进展[J]. 实用肿瘤学杂志, 2023, 37(1): 58-62.
[7]	李书桢, 蔡志福, 容雁, 庞业滨, 罗冬妮, 高琨. 肿瘤体积在宫颈癌近距离治疗中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(1): 63-67.
[8]	朱兴, 张冰, 赵静, 纪洪. 铁死亡在泌尿系统肿瘤中的作用及其机制研究进展[J]. 实用肿瘤学杂志, 2023, 37(1): 73-78.
[9]	曹文杰, 魏瑗, 邝栋明. 肿瘤浸润B细胞与免疫治疗[J]. 实用肿瘤学杂志, 2022, 36(6): 507-512.
[10]	张玥, 汪越, 魏嘉. SHP2作为抗肿瘤治疗靶点的价值及其在肿瘤免疫治疗中的应用[J]. 实用肿瘤学杂志, 2022, 36(6): 513-519.
[11]	那睿思, 郭影, 时佳琪, 郑桐森. 小肠肿瘤罕见原因[J]. 实用肿瘤学杂志, 2022, 36(6): 526-530.
[12]	王馨艺, 路一平, 孙峥嵘. m6A RNA甲基化修饰影响恶性肿瘤及肿瘤干细胞生物学特性的研究进展[J]. 实用肿瘤学杂志, 2022, 36(6): 551-555.
[13]	张淑敏, 张弓. ILC2s在肿瘤免疫调控中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(6): 566-569.
[14]	朱开彬, 贺长军, 陈澜涛, 孔祥龙, 赵苏, 徐世东. TAM通过PLGF/Flt-1和TGF-β1通路促进非小细胞肺癌生长和肿瘤血管异生的研究[J]. 实用肿瘤学杂志, 2022, 36(5): 391-397.
[15]	王钦, 刘军杰, 陆秀鑫, 吴雅菲, 张文皓. 基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(5): 429-434.

Kin17在肿瘤中的研究进展

Research progress of Kin 17 in tumors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价