实体瘤神经支配机制与靶向治疗研究进展

doi:10.11904/j.issn.1002-3070.2026.01.013

摘要/Abstract

摘要： 神经细胞与肿瘤细胞之间存在复杂的双向相互作用,这种相互作用对于机体稳态和新陈代谢至关重要。传统神经肿瘤学主要聚焦大脑和脊髓中的肿瘤,近年来肿瘤神经微环境受到关注。本文全面探讨神经系统和多种实体瘤之间的相互作用机制,旨在阐明神经系统对肿瘤进展的影响及其在肿瘤免疫中的作用。重点概述前列腺癌、胰腺癌、胃癌、肺癌、乳腺癌和结直肠癌等实体瘤中的神经支配特征,并进一步探讨靶向神经-肿瘤相互作用的潜在治疗策略。

关键词: 神经细胞, 癌症, 神经科学, 肿瘤免疫

Abstract: There are complex bidirectional interactions between nerve cells and tumor cells,which are critical for the body′s homeostasis and metabolism.Traditional neuro-oncology mainly focuses on tumors in the brain and spinal cord,and in recent years,the tumor neural microenvironment has received attention.This article comprehensively explores the interaction mechanisms between the nervous system and various solid tumors,aiming to elucidate the impact of the nervous system on tumor progression and its role in tumor immunity.This review focuses on the characteristics of neural innervation in solid tumors such as prostate cancer,pancreatic cancer,gastric cancer,lung cancer,breast cancer,and colorectal cancer,and further explores the potential therapeutic strategies targeting the neural-tumor interaction.

Key words: neural cells, cancer, neuroscience, tumor immunity

中图分类号:

R730

刘冠辰, 李环宇. 实体瘤神经支配机制与靶向治疗研究进展[J]. 实用肿瘤学杂志, 2026, 40(1): 89-96.

LIU Guanchen, LI Huanyu. Research progress on the neural innervation mechanism and targeted therapy of solid tumors[J]. Journal of Practical Oncology, 2026, 40(1): 89-96.

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