结直肠癌病人Vimentin表达的临床意义

doi:10.11904/j.issn.1002-3070.2015.04.007

Abstract

Abstract: Objective Vimentin is the major protein consisting of intermediate filaments in normal and neoplastic mesenchymal cells.It has been regarded as a marker of epithelial mesenchymal transition(EMT).However,little is known about colorectal cancer(CRC)with Vimentin expression as a marker of EMT and prognosis.Methods We investigated the expression of Vimentin in CRC tissues and determined the correlations between Vimentin expression patterns and clinicopathologic characteristics and prognosis in CRC.In total,189 patients diagnosed with CRC based on histopathological evaluation and those subjected to surgical resection at the Liaoning Province Cancer Hospital and Institute between 2000 and 2002 were examined.Immunohistochemical staining for Vimentin was performed for each specimen.Results Positive expression of Vimentin was significantly associated with the lymph node metastasis(pN stage,P=0.038),TNM stage(P=0.024).Survival analysis revealed that positive Vimentin expression was significantly related to poor prognosis(P=0.016).Multivariate analysis revealed that Vimentin expression was an independent prognostic factor for patient survival in colorectal cancer(P=0.026).Conclusion In Conclusion ,our data provide novel evidence for the clinical significance of Vimentin expression as potential predictive biomarkers for identifying patients with lymph node metastasis or poor prognosis in CRC.

Key words: Vimentin, Colorectal cancer, Epithelial-mesenchymal transition(EMT), Prognosis

CLC Number:

R735.3+4

GAO Zhaohua,ZHANG Hao,SHI Gang. Clinical significance of Vimentin expression in patients with colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 319-326.

References

1 Messerini L,Cianchi F,Cortesini C,et al.Incidence and prognostic significance of occult tumor cells in lymph nodes from patients with stage IIA colorectal carcinoma[J].Human Pathology,2006,37(10):1259-1267.
2 De Krijger I,Mekenkamp LJ,Punt CJ,et al.MicroRNAs in colorectal cancer metastasis[J].The Journal of Pathology,2011,224(4):438-447.
3 Iwatsuki M,Mimori K,Yokobori T,et al.Epithelial-mesenchymal transition in cancer development and its clinical significance[J].Cancer Science,2010,101(2):293-299.
4 Radisky DC.Epithelial-mesenchymal transition[J].Journal of Cell Science,2005,118(19):4325-4326.
5 Kalluri R,Weinberg RA.The basics of epithelial-mesenchymal transition[J].The Journal of Clinical Investigation,2009,119(6):1420-1428.
6 Mani SA,Guo W,Liao MJ,et al.The epithelial-mesenchymal transition generates cells with properties of stem cells[J].Cell,2008,133(4):704-715.
7 Tomaskovic-Crook E,Thompson EW,Thiery JP.Epithelial to mesenchymal transition and breast cancer[J].Breast Cancer Research,2009,11(6):213-222.
8 Gupta GP,Massague J.Cancer metastasis:building a framework[J].Cell,2006,127(4):679-695.
9 Steinert PM,Roop DR.Molecular and cellular biology of intermediate filaments[J].Annual Review of Biochemistry,1988,57:593-625.
10 Eckes B,Dogic D,Colucci-Guyon E,et al.Impaired mechanical stability,migration and contractile capacity in vimentin-deficient fibroblasts[J].Journal of Cell Science,1998,111(13):1897-1907.
11 Kang Y,Massague J.Epithelial-mesenchymal transitions:twist in development and metastasis[J].Cell,2004,118(3):277-279.
12 Thiery JP.Epithelial-mesenchymal transitions in tumour progression[J].Nature Reviews Cancer,2002,2(6):442-454.
13 Toiyama Y,Yasuda H,Saigusa S,et al.Increased expression of Slug and vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer[J].Carcinogenesis,2013,34(11):2548-2557.
14 Hamilton SR ALe.Pathology and genetics of tumours of the digestive system[M].France:IARC Press,2000:2.
15 Edge S BD,Compton C.AJCC cancer staging manual,7th ed[J].JAMA,2010,304(15):1726-1727.
16 Wu Y,Yamada S,Izumi H,et al.Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer[J].Journal of Surgical Oncology,2012,105(7):724-730.
17 Kouso H,Yano T,Maruyama R,et al.Differences in the expression of epithelial-mesenchymal transition related molecules between primary tumors and pulmonary metastatic tumors in colorectal cancer[J].Surgery Today,2013,43(1):73-80.
18 Grunert S,Jechlinger M,Beug H.Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis[J].Nature Reviews Molecular Cell Biology,2003,4(8):657-665.
19 Hugo H,Ackland ML,Blick T,et al.Epithelialmesenchymal and mesenchymalepithelial transitions in carcinoma progression[J].Journal of Cellular Physiology,2007,213(2):374-383.
20 Kokkinos MI,Wafai R,Wong MK,et al.Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo[J].Cells Tissues Organs,2007,185(1-3):191-203.
21 Ivaska J,Pallari HM,Nevo J,et al.Novel functions of vimentin in cell adhesion,migration,and signaling[J].Experimental Cell Research,2007,313(10):2050-2062.
22 Janosch P,Kieser A,Eulitz M,et al.The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments[J].FASEB J,2000,14(13):2008-2021.
23 Perlson E,Michaelevski I,Kowalsman N,et al.Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase[J].J Mol Biol,2006,364(5):938-944.
24 Liu LK,Jiang XY,Zhou XX,et al.Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome[J].Mol Pathol,2010,23(2):213-224.
25 Fuchs IB,Lichtenegger W,Buehler H,et al.The prognostic significance of epithelial-mesenchymal transition in breast cancer[J].Anticancer Research,2002,22(6A):3415-3419.
26 Ngan CY,Yamamoto H,Seshimo I,et al.Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer[J].British Journal of Cancer,2007,96(6):986-992.
27 Dauphin M,Barbe C,Lemaire S,et al.Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas[J].Lung Cancer,2013,81(1):117-122.
28 Gilles C,Polette M,Piette J,et al.Vimentin expression in cervical carcinomas:association with invasive and migratory potential[J].The Journal of Pathology,1996,180(2):175-180.
29 Lang SH,Hyde C,Reid IN,et al.Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma[J].The Prostate,2002,52(4):253-263.
30 Logullo AF,Nonogaki S,Pasini FS,et al.Concomitant expression of epithelial-mesenchymal transition biomarkers in breast ductal carcinoma:association with progression[J].Oncology Reports,2010,23(2):313-320.
31 Yamashita N,Tokunaga E,Kitao H,et al.Vimentin as a poor prognostic factor for triple-negative breast cancer[J].J Cancer Res Clin Oncol,2013,139(5):739-746.
32 Karihtala P,Auvinen P,Kauppila S,et al.Vimentin,zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers:association with an aggressive tumour phenotype[J].Breast Cancer Res Treat,2013,138(1):81-90.
33 Sudo T,Iwaya T,Nishida N,et al.Expression of mesenchymal markers vimentin and fibronectin:the clinical significance in esophageal squamous cell carcinoma[J].Ann Surg Oncol,2013,20(Suppl 3):S324-335.
34 Jin H,Morohashi S,Sato F,et al.Vimentin expression of esophageal squamous cell carcinoma and its aggressive potential for lymph node metastasis[J].Biomed Res,2010,31(2):105-112.
35 Tobler NE,Detmar M.Tumor and lymph node lymphangiogenesis—impact on cancer metastasis[J].J Leukoc Biol,2006,80(4):691-696.

[1]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[2]	FENG Yue,XING Linan,WANG Zhao,ZHANG Yunyan. Correlation between NLR and prognosis of concurrent chemoradiotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 284-288.
[3]	BAI Xiaobin, HUO Longwei, XIE Wanfu, XU Gaofeng, WANG Maode. Expression of Chk1 in glioblastoma and its association with tumor biological behavior and prognosis survival [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 122-127.
[4]	SHI Xiaokang, DING Youming, WANG Bin, YU Bin, XU Yu. Expression and clinical significance of UBE2T in primary liver cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 128-133.
[5]	FANG Lin, LIU Chao, ZHANG Chunhui, ZHANG Yanqiao. Research status and treatment strategies of maintenance therapy for metastatic colorectal cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 173-178.
[6]	TONG Guanghai, TIAN Yang, WU Huaxing. Application of lipidomics in colorectal cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 179-192.
[7]	LU Jiaoyun, ZHANG Qingyuan. Advances in laboratory markers in the prognosis of diffuse large B-cell lymphoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 183-187.
[8]	LIU Hengchen, ZHANG Xinyu. Toll-like receptor signaling pathway as a potential therapeutic target for colorectal cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 188-192.
[9]	ZHAO Fengjuan, WANG Qi, REN Yunhong, WEI Jueling, LI Lequn, ZHAO Xinhua, TANG Juan, YOU Xuemei. Changes of serum CRP and hs-CRP levels in patients with liver cancer and depression and their influence on prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 27-33.
[10]	ZHANG Fengchun, JIANG Ying, LIU Zhaonan, YAN Ningning, CUI Hongquan, XU Yingchun. Prognostic significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in systemic inflammation-related indicators in gastric cancer patients after radical resection [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 34-39.
[11]	MA Jianli, ZHANG Minghui, JI Hongfei, XU Xiangying. Clinical significance of combined detection of PD-L1 protein and CD8⁺TILs in resected lung adenocarcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 40-46.
[12]	YANG Hongbo, SHI Jie, YE Yong, LI Wencheng, DENG Zhaoping. Expression of COL5A2 in bladder cancer tissues and its correlation with clinicopathological features and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 52-56.
[13]	WANG Yalong, LYU Zhangyan, ZHANG Fan, FENG Xiaoshuang, WEI Luopei, LI Xin, WEN Yan, GAO Yushun, XUE Qi, GAO Shugeng, TAN Fengwei. Relationship between human papillomavirus infection and prognosis of lung cancer:A meta-analysis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 520-526.
[14]	TANG Shuli, HE Kuangbang, ZHANG Chunhui, CHENG Jianan, ZHANG Yanqiao. Expression of miR-320a and CYLD in gastric cancer and its relationship with clinicopathological characteristics and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 538-544.
[15]	XIAO Hongwei, CHEN Sheng, WANG Yanliang, SU Xueliang. The prognostic and influence factors analysis of transanal local resection for stage T₁ rectal cancer with the distance from anal margin ≤8 cm [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 545-549.

Clinical significance of Vimentin expression in patients with colorectal cancer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments