靶向血管生成拟态治疗肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2015.04.016

Abstract

Abstract: Tumor microvessel including two modes,as one is classic vascular structures surrounded with vascular endothelial cells and the other is vasculogenic mimicry(VM)surrounded with cancer cells.Recent studies suggested that anti-angiogenic drugs can inhibit classic microvessel structure significantly,but can not inhibit VM formation and even promote VM formation further more.This is one of the reasons affecting its clinical efficacy.However,basic research has shown that traditional chinese medicine,gene therapy and drugs which is targeting for VM formation have an unique advantage in anti-VM.In this review,we summarize the progress of cancer therapy on targeting vasculogenic mimicry,and provide a basic for the development of new drugs for cancer therapy through targeting both angiogenesis and VM formation.

Key words: Vasculogenic mimicry, Cancer therapy, Antiangiogenic

CLC Number:

R735.3

LI Furong,CHENG Xianshuo,LI Yunfeng. Advances in cancer therapy by targeting vasculogenic mimicry[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 359-363.

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Advances in cancer therapy by targeting vasculogenic mimicry

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