OLC1在结直肠癌中的表达及对预后影响的研究

doi:10.11904/j.issn.1002-3070.2015.05.002

Abstract

Abstract: Objective The overexpression lung cancer1(OLC1)protein is overexpressed in a variety of human tumors.The purpose of the present study is to determine whether increased expression of OLC1 is associated with colorectal cancer.Methods OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining(IHC).Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis.Results Immunohistochemical Results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1.OLC1 expression was significantly correlated with UICC stage(P＜0.001)and histological differentiation(P＜0.001)in colorectal cancer patients.The 5-year overall survival(OS)rates in patients with strong positive and less OLC1 staining were 16.6% and 95.3%,respectively(P＜0.0001).Conclusion OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.

Key words: Overexpressed in lung cancer 1(OLC1), Colorectal cancer, Immunohistochemistry, Prognosis

CLC Number:

R735.3⁺4

LIU Jinglei, JIANG Ji, ZHANG Mingyan, WANG Ying, YOU Yan, WANG Yan. Over expression lung cancer-1 is associated with poor prognosis in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 390-394.

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Over expression lung cancer-1 is associated with poor prognosis in colorectal cancer

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