Abstract: Objective To investigate the relationship between dyslipidemia and distant metastases in patients with hormone receptor(HR)negative breast cancer,and to explore the impact of blood lipid change during chemotherapy on clinical response.Methods We collected the complete clinicopathological data and fasting blood lipid in 154 patients with HR negative breast cancer.The secondary blood lipid level were measured on day14 after two cycles of chemotherapy in patients with distant metastases.Single factor chi-square test was choosen to analyze the relationship between clinicopathological characteristics,including baseline lipid level,and distant metastases,then independent risk factor for distant metastases were evaluated by logistic regression model.Data about altered blood lipid and clinical response analysis were performed using paired t-test pre-or post-chemotherapy.Results Our Results from single chi-square test showed that distant metastasis from breast cancer was significantly associated with tumor size,local lymph node metastases,grade,higher total cholesterol(TC),higher triglycerides(TG)and higher low-density lipoprotein(LDL)(P＜0.05).For distant metastases,independent risk factors were tumor size(OR=1.563),local lymph node metastases(OR=1.983),higher TC(OR=1.502),higher TG(OR=1.877).Decreased trend of TC,TG and LDL and increased trend of HDL were showed in disease control(PR+SD)group,and TG had significantly tend in Objective response(PR)group.Conclusion Hyperlipidmia is significantly associated with distant metastases in patients with HR negative breast cancer,and blood lipid levels decrease with effective anti-tumor chemotherapy.Dynamic monitoring of blood lipid levels could be a candidate surrogate biomarker for outcome prediction and distant metastases in patients with HR negative breast cancer.

Key words: Blood lipid, Distant metastases, Hormone receptor negative, Breast cancer, Clinical response