Abstract: Chemotherapy is one of the primary treatments for cancer patients,while tumor multidrug resistance(MDR)represents a major obstacle in the treatments of patients,limiting the efficacy of chemotherapy.To date,the mechanism of drug resistance has not been fully elucidated.lncRNAs are a family of long noncoding RNAs that regulate gene expression by epigenetic modification,transcription and post transcriptional processing.Recent studies have showed that the aberrant regulation of target genes by lncRNAs may be involved in the acquisition of tumor MDR.Therefore,targeting lncRNAs may be an attractive strategy for improving the chemosentivity and reversing chemotherapeutic resistance.This paper reviews the relationship between lncRNAs and tumor drug resistance as well as the underlying possible mechanism.

Key words: LncRNAs, Tumor multidrug resistance, Gene expression regulation