Abstract: Objective To investigate the efficacy and safety of HCPT combined with 5-fluorouracil(5-Fu)in treatment of bladder cancer.Methods Selected 92 patients with advanced bladder cancer in our hospital from February 2011 to August 2015,equally divided into observation group and control group of 46 patients based on the random number table,the control group were received 5-Fu intravesical chemotherapy,The observation group were given the HCPT combined with 5-Fu chemotherapy,the chemotherapy infusion were once a week,continuous perfusion were observed for 3 months.Results The response rates in the observation group was 95.7% and the control group was 76.1%,the observation group were significantly higher than the control group(P＜0.05).The occurrence of bladder irritation adverse reaction,blood abnormalities,liver and kidney dysfunction,bone marrow suppression in the observation group during chemotherapy compared with the control group were no significant difference(P＞0.05),all adverse reactions after symptomatic treatment were improved.All patients were followed up for 1 year,The mortality and recurrence rates in the observation group were 8.7% and 4.3% respectively,while the control group were 30.4% and 17.4%,the mortality and recurrence rates of the observation group were significantly lower than the control group(P＜0.05).Conclusion HCPT combined with 5-Fu chemotherapy for bladder cancer has strong anti-cancer effect and without increase the incidence of adverse reactions,it can promote the improvement of the long-term prognosis,so it is a safe and effective topical bladder chemotherapy drugs.

Key words: HCPT, 5-Fu, Bladder cancer, Intravesical instillation of chemotherapy, Safety