PRACTICAL ONCOLOGY JOURNAL ›› 2009, Vol. 23 ›› Issue (4): 336-338.doi: 10.3969/j.issn.1002-3070.2009.04.011
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YUE Xiaolong, LIU Wenming
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Abstract: Objective To compare the recently curative, noxious and side effects of drug combination of CPT-11 plus CAP and 5-Fu/CF in the treatment of advanced colorectal cancer.Methods 77 cases of advanced colorectal cancer diagnosed by pathology and histology were divided into 2 groups randomly.Experimental group(39 cases):CPT-11100mg/m2 was injected in 90 minutes in d1, 8, capecitabine 1000mg/m2 was taken twice a day in d1-14.Control group(38 cases):CF 200 mg was injected in d1, 2, followed by the injection of 5-Fu 400mg/m2 in d1, 2 and the micro pumping of 5-Fu 600mg/m2 over 48 hours in d2.The treatment was repeated every three weeks as one cycle and the treatment effect was evaluated after 2 cycles.Results The total effective rates of experimental group(39 cases)and control group(38 cases)are 48.7%(19cases)and 21.1%(8 cases), respectively.There is statistical significance between the two groups(P< 0.025).The main noxious and side effects were delayed diarrhea, leucopenia, nausea and vomiting, etc.There was no treatment related death.Conclusion The curative effect of drug combination of CPT-11 plus CAP is superior to 5-Fu/CF in the treatment of advanced colorectal cancer and the combination was recommended to be used widely.
CLC Number:
R735.34
YUE Xiaolong, LIU Wenming. Comparative study of drug combination of CPT-11 plus CAP and 5-Fu/CF in the treatment of advanced colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2009, 23(4): 336-338.
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