内质网应激PERK通路在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.01.007

Abstract

Abstract: During growth,invasion and metastasis,tumor cells undergo endoplasmic reticulum stress(ERS)under hypoxia,hypoglycemia and other environmental stresses.In response to ERS,tumor cells induce unfolded protein response(UPR).PERK signaling pathway as a key pathway to activate UPR can promote survival,proliferation,invasion and protection of tumor cells by increasing tumor tolerance to adverse microenvironment,inducting angiogenesis,inducing autophagosome formation and activating apoptotic signal molecules.Tumor cells are induced apoptotic and autophagic death when UPR reaches a certain extent.

Key words: ERS, UPR, Tumor cells, PERK signaling pathway

CLC Number:

R730

OUYANG Zhongrui, CHAI Shuang, ZHAO Haiqi, LIU Yaohua. Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 38-41.

References

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Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor

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