雌激素受体相关受体γ在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.01.017

Abstract

Abstract: Estrogen receptor-related receptor γ(ERR γ)belongs to the orphan nuclear receptor family(NRs),which can regulate the expression of multiple genes in the absence of natural ligands and play an important role in maintaining the basic biological activities of cells.In recent years,the data from many studies have shown that ERR γ is involved in the development and progression of tumor,including tumor cell metabolism,proliferation,metastasis and angiogenesis.Besides,the effect of ERR γ on tumor progression and prognosis has the specificity of cell and tissue.This paper will review the clinical significance of ERR γ and its mechanism in metabolism and tumors related estrogen ,which provided the theoretical basis for metabolism and estrogen-related tumorigenesis and targeted therapy.

Key words: Estrogen receptor-related receptor γ, Tumor, Metabolism, Proliferation, Metastasis

CLC Number:

WANG Xiaoxiao, HUA Teng, WANG Hongbo. Research progress of estrogen receptor-related receptor γ in tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 87-91.

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Research progress of estrogen receptor-related receptor γ in tumors

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