PRACTICAL ONCOLOGY JOURNAL ›› 2018, Vol. 32 ›› Issue (3): 263-266.doi: 10.11904/j.issn.1002-3070.2018.03.015

• Review • Previous Articles     Next Articles

Research progress and clinical significance of QKI protein in malignant tumor

ZHANG Ting,HOU Guangying,WANG Xin,HE Yan   

  1. 1.Department of Pathology,Harbin Medical University,Harbin 150081,China;
    2.Department of Oncology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine;
    3.Department of Otorhinolaryngology and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University
  • Received:2017-06-22 Online:2018-07-10 Published:2018-07-10

Abstract: QKI protein is a kind of STAR protein family and mainly contains three subtypes of QKI-5,QKI-6 and QKI-7.Early studies showed that QKI protein is closely related to the development of nerve myelin and embryo.With the development of molecular biology and the extensive application of gene technology,the effect of QKI protein on malignant tumors has received increasing attention.The studies of QKI protein from lung,gastric and prostate cancers have shown that it has the ability to inhibit tumor invasion,and may become a new target for the diagnosis and treatment of malignant tumors.Although significant progress has been made in the extensive research of QKI protein in malignant tumors,there are still many doubtful points that need to be answered.Thus,further research and exploration of QKI are needed in malignant tumor.

Key words: QKI protein, Malignant tumor, Tumor suppression

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