Abstract: Objective The objective of this study was to investigate and understand the life quality and its influencing factors in breast cancer patients with chemotherapy. Methods Based on the European Research and Treatment Association,the EORTC-BR53 scale consisting of QLQ-C30 and QLQ-BR23 was used as the main basis to design a questionnaire to investigate the life quality of breast cancer patients with chemotherapy.The rank sum test was used to evaluate the survival of breast cancer patients with chemotherapy.The grade logistics univariate and multivariate analyses were used to analyze the factors of prognosis and life quality of breast cancer patients. Results The median fun scores of QLQ-BR23 scale in the groups of ＜35 months,36~59 months and more than 60 months were 0,0,and 66.67,respectively(P＜0.05).The median scores of annoy caused by alopecia were 33.33,33.33,and 10.33 in three groups mentioned above,respectively(P＜0.05).The median scores of physical function of QLQ-C30 scale for modified radical mastectomy,segment plus sentinel and breast-conserving patients were 66.67,66.67,and 73.33,respectively(P＜0.05).The median scores of nausea and vomiting in the modified radical mastectomy was 16.67,and others were 0;the median scores of shape physique of QLQ-BR23 in three groups were 91.67,100 and 100,respectively(P＜0.05);the median scores of sexual function were 0,16.67 and 50,respectively(P＜0.05),and the median scores of sexual fun were 0,33.33 and 66.67,respectively(P＜0.05).To analyze the total symptoms of life quality,causing borrow money and pathological classification were the factors affecting the total life quality of breast cancer patients with chemotherapy(P＜0.05).The total symptoms of life quality were analyzed.Univariate analysis showed that borrows money due to illness and ductal carcinoma in pathological classification had significant. Conclusion The life quality of breast cancer patients with chemotherapy is mainly related to the pathological stage of patients and whether they have economic pressure.

Key words: Breast cancer, Quality of life, Influencing factors, Chemotherapy