RNA结合蛋白Lin28在恶性肿瘤发生发展中的作用和分子机制

doi:10.11904/j.issn.1002-3070.2019.05.014

Abstract

Abstract: The RNA binding protein Lin28 is expressed in a variety of malignant tumor tissues.The certain transcription factors and RNA binding proteins can up-regulate the expression of Lin28 at both transcription and post-transcription levels.The high level of Lin28 can induce malignant transformation of normal cells by affecting the expression of miRNA or regulating the transcription,splicing,stability and translation of target mRNA,and can promote the proliferation and metastasis of tumor cells.The high expression of Lin28 has an important role in inducing tumorigenesis and progression,and is also an important biomarker for assessing the prognosis of malignant tumors.This review summarizes the existing literature about the role of Lin28 in malignant tumors,the molecular mechanisms of upregulation,and the downstream regulatory mechanisms at the time of action,which is of great significance for fully understanding the Lin28 molecule.

Key words: Lin28, Malignant tumor, Molecular mechanism

CLC Number:

R730.2

LI Yafei, ZHANG Xiao, WANG Xuefei, WENG Mingjiao, WANG Tianzhen. Effect of RNA-binding protein Lin28 on the development of malignant tumors and its molecular mechanism[J]. Journal of Practical Oncology, 2019, 33(5): 456-460.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2019/V33/I5/456

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Effect of RNA-binding protein Lin28 on the development of malignant tumors and its molecular mechanism

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