Journal of Practical Oncology ›› 2023, Vol. 37 ›› Issue (2): 107-111.doi: 10.11904/j.issn.1002-3070.2023.02.003

• Cancer Surveillance • Previous Articles     Next Articles

The disease burden of breast cancer attributed to metabolic risk factors in the Chinese female population,from 1990 to 2019

ZHANG Xin1, WU Xianmei2, LI Hong1, LIU Xiaozhou1, KONG Dewen1, CHEN Zhuo3   

  1. 1. The First Ward of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China;
    2. The Second Ward of Head,Neck,Nose and Throat,Harbin Medical University Cancer Hospital;
    3. Department of Anesthesiology,Harbin Medical University Cancer Hospital
  • Received:2023-02-12 Revised:2023-04-06 Online:2023-04-28 Published:2023-05-30

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Abstract: Objective The Objective of this study was to analyze the changing trend of breast cancer disease burden attributable to metabolic risk factors in Chinese female population between 1990 and 2019,so as to provide scientific basis for formulating targeted prevention and control strategies. Methods Based on the global burden of disease study 2019(GBD 2019)database,mortality,disability adjusted life year(DALY),disability adjusted life year(DALY),years lived with disability(YLD),years of life lost(YLL),and population attributable fraction(PAF)were calculated to analyze the changing trend of breast cancer disease burden attributed to metabolic risk factors in Chinese female population. Results The age-standardized mortality and the DALY rate of breast cancer attributable to metabolic risk factors in China and the World both showed an upward trend between 1990 and 2019.The attributable age-standardized mortality and DALY rate in China increased by 1.79%(95% CI:1.51%-2.07%,P＜0.05)and 1.77%(95% CI:1.45%-2.09%,P＜0.05),the global attributable standardized mortality and DALY rate increased by 0.80%(95% CI:0.69%-0.92%,P＜0.05)and 0.97%(95% CI:0.91%-1.04%,P＜0.05),respectively,and the increase in China was higher than that in the World.There were differences in the PAF attributable to metabolic risk factors of breast cancer among Chinese women in different age groups between 1990 and 2019,and the PAF value was higher in the age group of 50-69 and over 70 years old.The attributable DALY rate was the highest in the age group of 50-69,and the attributable mortality increased with age,reaching the highest in the ≥70-year-old age group.Compared with 1990,the number of breast cancer deaths and DALY caused by high body mass index among metabolic risk factors in 2019 increased by 450.34% and 440.28%,respectively,and the mortality and DALY rate increased by 352.48% and 344.20%,respectively. Conclusion The burden of breast cancer in Chinese female population is heavy due to metabolic risk factors,and middle-aged and elderly female population is a high-risk group.In addition,high body mass index is an important risk factor among metabolic risk factors.

Key words: China, Breast cancer, Metabolic risk factors, Burden of disease

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