Abstract: Objective To investigate the effects of cranberry and tomato extraction on tumor proliferation, apoptosis and angiogenesis in breast cancer animal model.Methods The nude mice bearing MCF-7 breast caner cell were set up and divided into several groups.They received cranberry extraction, tomato extraction and cranberry and tomato extraction by gavage respectively.Tumor cell proliferation was detected by bromouracil deoxyriboside labeling(BrdU), cell apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL), and tumor microvascular density immunohistochemical method(CD34 antibody).Results The tumor proliferative index and microvascular density were decreased in cranberry group, tomato group and cranberry and tomato group compared with control, and the apoptotic index increased in cranberry and tomato group.The difference was statistically significant.Conclusion The cranberry and tomato extraction can inhibit tumor proliferation, promote apoptosis and decrease angiogenesis in breast cancer.The synergy of different agents helps to enhance the antitumor effects, and it has potential value for application in cancer treatment.