Abstract: Objective To investigate the expression of RET and VEGF-C in papillary carcinoma of thyroid,Soasto the role and correlation of RET and VEGF-C.Methods Detecting the expression of RET and VEGF-C in 60 papillary carcinoma of thyroid tissues and 10 normal thyroid tissues by immunohistoche mical Envision two-step method,analyzing the correlation between the protein expression rate and clinical and pathological characters,and also the correlation between the expression of RET and VEGF-C.Results Expression of every oncogene was significantly different between papillary carcinoma of thyroid tissues and normal thyroid tissues(P＜0.05).The positive expression rate of RET and VEGF-C were significantly associated with cervical lymph node metastasis and clinical stages(P＜0.05),but not associated with sex,age,primary site of the tumor(P＞0.05).The positive expression of RET closely related to the positive expression of VEGF-C(P＜0.05).Conclusion The results demonstrate that RET may play an important role in the cervical lymph node metastasis of papillary carcinoma of thyroid,the expression of VEGF-C.RET and VEGF-C should be used as an important marker of cervical lymph node metastasis.