Abstract: Objective There are many factors associated with the prognosis of the patients with low grade gliomas(LGG).In some cases,the prognosis of the patients with low grade glioma differ completely,althrough using the same treatment.Some of the patients with LGG soon reccured after operation,following by malignant development.The prognosis of these patients was very poor.This stduy was to detect the changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma.Methods The expressions of VEGF and EGFR in 24 pairs of cases with primary LGG as well as recurrent and malignant development were examined by using immunohistochemical SP method.The different expressions of VEGF and EGFR in the patients with LGG as well as recurrent and malignant development were analyzed.Results The expressions of VEGF and EGFR in the patients with recurrent and malignant development were significantly increased,compared with the patients with primary LGG(P＜0.05).Conclusions The expressions of VEGF and EGFR played an important role in the patients with recurrent and malignant development of low grade gliomas.The expressions of VEGF and EGFR may be used as an indicator of poor prognosis for the patients with low grade glioma.It also provided a theroic basis of target therapy for the patients with glioma.