PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (5): 469-473.doi: 10.3969/j.issn.1002-3070.2012.05.019

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Novel insights on the regulation of tumorigenesis and drug resistance based on hypoxia inducible factor-1alpha

WU Zheming1,CHENG Li2   

  1. 1.Clinical Bachelor of Class 2009 of Chengdu Medical College,Chengdu 610083,China;
    2.Morphology Teaching and Research Section of Chengdu Medical College,Chengdu 610083
  • Received:2012-05-29 Online:2012-05-25 Published:2012-10-29

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Abstract: Recently,Hypoxia inducible factor-1α(HIF-1α)has been extensively investigated as an important biomarker of carcinogenesis.Studies have revealed that it can regulate angiogenesis and glycolysis,and also induce metastasis in malignant tumors.Therefore,it is closely related to multi-drug resistance in malignancies.The progress on HIF-1α research will provide deep understanding of multi-drug resistance mechanism.The relationship between HIF-1α and multi-drug resistance in malignancies was summarized in this review.

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