Abstract: Objective To explore the expressions of AEG-1 and DLL4 in endometrial carcinoma and detect their clinical significance and pathologic parameters.Methods The expressions of AEG-1 and DLL4 were measured by immunohistochemical method,including 40 cases with normal endometrium specimens and 152 cases with malignant tumor.The relationship between AEG-1,DLL4 expression and clinicopathological factors was also assessed in these patients.Results The positive expression rate was significantly higher in malignant than that in benign group(P＜0.01).The positive expression rate of AEG-1 was not associated with age and pathologic types(P＞0.05),but with the clinical stage FIGO stage and metastasis(P＜0.05).The positive expression rate of AEG-1 was high in those low differentiation degree,advanced stage and metastasis present cases.Conclusion AEG-1 and DLL4 play a key role in endometrial carcinoma occurrence and development.The expressions of AEG-1 and DLL4 are quite helpful in diagnosis and clinicopathologic grade of endometrial carcinoma.