MMP-3和p53蛋白在乳腺癌组织中的表达及其与肿瘤转移的关系

Abstract

Abstract: Objective To study the significance of MMP-3 and p53 expression in patients with mammary carcinoma. Methods The expression of MMP-3 and p53 were detected by immunohistochemical S-P in 58 mammary infiltration duct carcinoma tissue samples and their clinical data were statistically analysed. Results In 58 mammary carcinoma tissue samples, the expression of MMP-3 was 44.83% and the expression of p53 was 37.93%.The expression of MMP-3 was correlated significantly with lymph node metastasis, P＜0.05;The expression of p53 was correlated significantly with the size of cancer, P＜0.05. Conclusions The expression of MMP-3, p53 can be taken as the biological marker of prognosis and postoperative comprehensive treatment of breast cancer.

Key words: Mammary infiltration duct carcinoma, Matrix metalloproteinases-3, p53

CLC Number:

R364.7 R737.9

XIAO Min, HUANG Sunhui. Expression and clinical significance of MMP-3 and p53 in mammary carcinoma
[J]. PRACTICAL ONCOLOGY JOURNAL, 2008, 22(6): 514-516.

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Expression and clinical significance of MMP-3 and p53 in mammary carcinoma

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