AKR1C2与Twist在胃组织中的表达及其临床病理相关性的研究

doi:10.3969/j.issn.1002-3070.2012.05.002

Abstract

Abstract: Objective To investigate the expressions of Aldo-Keto Reductase 1C2(AKRlC2)and Twist in different gastric tissues and their clinical pathological relations.Methods Immunochemical method is used to detect AKRlC2 and Twist expressions in 156 cases of gastric carcinoma,31 cases of atypical hyperplasia and 20 cases of normal gastric tissues.The correlation of the two expressions was compared.Results The expression of AKR1C2 was not detected in all 20 normal gastric tissue cases.But,Its expression was up-regulated in 6 atypical hyperplasia cases from 31 and 86 gastric carcinoma cases from 156.There was statistical significance in latter(P＜0.01).The expression of Twist was not detected in 19 normal gastric tissue cases from 20.But the expression of it was up-regulated in 3 atypical hyperplasia cases from 31 and 107 gastric carcinoma cases from 156.There was statistical significance in latter(P＜0.01).The expressions of AKR1C2 and Twist in gastric carcinoma were positively related(P＜0.01).The expression of AKR1C2 in different gastric tissues has statistical significance(P＜0.01).Conclusion AKRIC2 and Twist could be used as bio-markers for diagnosis and prognosis of the gastric carcinoma.In addition,AKRIC2 may be involved in Epithelial-Mesenchymal Transition(EMT).

CLC Number:

R737.33

LYU Wei,FENG Meiyan,SONG Hongtao,JIANG Ying,TONG Dandan,LI Yulian,SHI Qingtao,GENG Jingshu. To study AKR1C2 and Twist expressions in various gastric tissues and the clinical pathological relations of AKR1C2 and Twist[J]. PRACTICAL ONCOLOGY JOURNAL, 2012, 26(5): 389-393.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.3969/j.issn.1002-3070.2012.05.002

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2012/V26/I5/389

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To study AKR1C2 and Twist expressions in various gastric tissues and the clinical pathological relations of AKR1C2 and Twist

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