PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (5): 410-413.doi: 10.3969/j.issn.1002-3070.2012.05.006

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Expression and its clinical significance of PAK1 mRNA in laryngeal cancer

HE Guoqing1,GUAN Qiang1,ZHANG Xijun2,ZHANG Jiewu1,JI Hongfei3,XU Jin4   

  1. 1.Department of Head and Neck,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081,China;
    2.Department of Otolaryngology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001;
    3.The Institute of Cancer Prevention and Treatment of Harbin Medical University,Harbin 150081;
    4.Cell and Biology Laboratory,Basic Medical Institute,Harbin Medical University,Harbin 150081
  • Received:2011-11-02 Online:2012-05-25 Published:2012-10-29

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Abstract: Objective To explore the expression level and clinical significance of PAK1 mRNA in laryngeal squamous cell carcinoma.Methods The mRNA expression level of PAK1 was detected in laryngeal cancer samples and matched para-cancerous normal tissues by real-time quantitative RT-PCR(qTR-PCR).Results The positive rate of PAK1 mRNA expression was 72.58% in laryngeal cancer.The high level of PAK1 mRNA was correlated with poor differentiation,lymph node metastasis,advanced clinical stage and poor prognosis(P＜0.05).Conclusion Our study demonstrated that up-regulation of PAK1 mRNA may closely correlated with the carcinogenesis and development of laryngeal cancer.It indicates that PAK1 may serve as a new therapeutic target for laryngeal cancer.

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