PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (5): 405-409.doi: 10.3969/j.issn.1002-3070.2012.05.005

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Expression of AEG-1 and Caspase-3 in triple negative basal-like breast cancer and their clinicopathological relationship

WANG Hongmei1,CAI Jianping1,LI Yinghong2,LIU Junjun1,ZHAO Yulan1,LI Lejing2,GENG Jingshu1   

  1. 1.Department of Pathology,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081,China;
    2.Department of Medical Oncology,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081
  • Received:2011-10-11 Online:2012-05-25 Published:2012-10-29

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Abstract: Objective To prove AEG-1 and Caspase-3 expressions of basal-like cancer tissues and their relevance.Methods HE staining was used to verify the pathological diagnosis of cases.Immunohistochemistry was used to detect the expression of AEG-1 and Caspase-3 in 66 basal-like cancer.Results 66 cases were all basal-like cancer,respectively.The positive expression rates of AEG-1 and Caspase-3 were 73% and 60% in basal-like cancer,respectively.The expression of AEG-1 in basal-like cancer tissues increased with the reduction of the differentiation level,and significantly higher in basal-like cancer with CA153 high than that in basal-like cancer without CA153 high,(P＜0.05).The expression of Caspase-3 in basal-like cancer tissues decreased with the reduction of the differentiation level,and was significantly lower in basal-like cancer with CA153 high than that in basal-like cancer without CA153 high(P＜0.05).AEG-1 and Caspase-3 expressions in basal-like breast cancer tissues were negatively correlated,however it was not statistically significant(P＞0.05).Conclusion AEG-1 and Caspase-3 maybe participate in progression of basal-like cancer.But,AEG-1 does not directly inhibit the expression of Caspase-3.It maybe interact with the CA153,as a cofactor in inhibiting the expression of Caspase-3.

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