脑胶质瘤中CDK4和β-Catenin表达及临床意义的研究

doi:10.11904/j.issn.1002-3070.2015.05.005

Abstract

Abstract: Objective To study the expression of CDK4 and β-Catenin and their relevance in glioma.Methods We used immunohistochemistry to detect the expression of CDK4 and β-Catenin in forty-five glioma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 and β-Catenin expressions between normal tissues and glioma tissues(P＜0.01).The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased(P＜0.05).Furthermore,the expression of CDK4 was positively correlated with the expression of β-Catenin in glioma(r=0.52,P＜0.01).Conclusion The increased expression of CDK4 and β-Catenin may have correlation with malignant change of glioma and occurance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.

Key words: Glioma, CDK4, β-Catenin

CLC Number:

R739.41

DONG Tianhua, SHEN Xin, LIANG Yanan, LIU Yu, TONG Dandan. The research on CDK4 and β-Catenin expression and clinic significance in glioma[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 404-408.

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The research on CDK4 and β-Catenin expression and clinic significance in glioma

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