Abstract: We have confirmed that many of the intraepithelial neoplasia confined to in situ may never be found in some patients,such as breast,prostate and lung lesions,but few of these lesions progress to malignancy are unexplained.Studies demonstrate that many invasive neoplasia and its precancerous lesions with similar genes changes,which provide the necessary premise for the late tumor metastatic,just like specific promoter mutations driving the cancer development,but the current radical view is that the mutations of the genes are not the driver of cancer development,rather the microenvironment of the cells inhibits or promotes the development of tumor.General view is that the epithelial cells are changed before the cell matrix in the development of neoplasia,but recent evidences show that the cell matrix is the first to change.This paper will focus on how matrix changes affect the epithelial tumor development,and this will bring new breakthrough for controlling epithelial tumors.

Key words: Epithelial tumors, Cell matrix, Field cancerization