Abstract: Objective To explore the applied value of urine light chain κ、λ and κ/λ ratio test in older people with B cell malignant proliferative disease.Methods Young volunteers,general older patients,kidney failure older patients and older patients with B cell malignant proliferative disease were selected and immunoephelometry method was applied to detect the level of urine light chain κ、λ and κ/λ ratio.Result The average levels(mg/L)of urine light chain κ and λ in older patients with kidney failure group(172.00±188.10,111.50±109.32)were higher than that in general older patients group(32.72±33.60,15.02±15.58).In each of the older patients groups,the levels of urine light chain κ and λ were higher than that in young volunteers groups(9.30±5.80,4.97±2.61).The κ/λ ratios of urine light chain in older patients with kidney failure group(1.59±0.4),general older patients group(2.19±0.54)and young volunteers group(1.92±0.48)were consistent,however,it was significantly abnormal in older patients with B cell malignant proliferative disease group,the ratio was high in κ type(44.8±83.17)and low in λ type(0.06±0.08).After effective treatment,κ/λ ratio of urine light chain in older patients with B cell malignant proliferative disease tended to normal.Conclusion The level of urine light chain κ and λ is effected by renal function,but not involved the κ/λ ratio.B cell malignant proliferative disease significantly affects the κ/λ ratio of urine light chain.Constantly monitoring the change of κ/λ ratio of urine light chain in older peoples with B cell malignant proliferative disease can reflect the proliferative degree of malignant B cell in vivo.

Key words: κ/λ ratio, Urine light chain, Older, B cell, Proliferation