角化棘皮瘤消退机制的研究进展

doi:10.11904/j.issn.1002-3070.2017.01.018

Abstract

Abstract: Keratoacanthoma(KA)is an epithelial neoplasm occurring in sun-exposed skin of the elderly.Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nosological position on the border between benignity and malignancy.The regression of KA may be associated with the hair follicle cycle,apoptosis and immune function of organism.This article summarizes physiological mechanisms such as Wnt/retinoic acid signalling cross-talk,the function of p53,bcl-2,bcl-xL and bak in apoptosis,and the mechanism of action of several immune-related cells,that drives KA regression.It can provide theoretical basis for us to select the method as well as time of the treatment in KA.

Key words: Keratoacanthoma, Hair follicles cycle, Apoptosis, Immunity

CLC Number:

R739.5

LIU Bingmei, CHENG Xue, XING Ronggui, YANG Jing. Progress in the mechanisms of keratoacanthoma regression[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 83-87.

References

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Progress in the mechanisms of keratoacanthoma regression

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