输血相关性铁过载在血液肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2017.01.017

Abstract

Abstract: Transfusion-related iron overload damage iron homeostasis of organism,which damages the structure of the vital organs and leads to the dysfunction of important organs.Iron overload affects the prognosis of the patients,which promotes myelodysplastic syndrome transformation to acute leukemia and reduces the total survival rate of patients with hematopoietic stem cell transplantation,which increases the treatment related mortality after hematopoietic stem cell transplantation and increases the chance of infection.Iron depletion therapy can delay the progression of acute leukemia and prolong the survival time of the patients with acute leukemia and show a certain anti-proliferative activity.

Key words: Transfusion-related iron overload, Myelodysplastic syndrome, Hematopoietic stem cell transplantation, Prognosis

CLC Number:

R733.7

DU Yaru, ZHAO Yanhong, ZHOU Jin. The research progress in transfusion-related iron overload in hematological malignancies[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 78-82.

References

1 Goldberg SL,Chen E,Corral M,et al.Incidence and clinical complications of myelodysplastic syndromes among United States Medicare beneficiaries[J].J Clin Oncol,2010,28(17):2847-2852.
2 Gattermann N,Finelli C,Della PM,et al.Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes[J].Haematologica,2012,97(9):1364-1371.
3 黄蕾,付蓉,邵宗鸿.铁过载组织损伤特点及机制研究进展[J].中华血液学杂志,2012,33(10):884-887.
4 Chiabrando D,Vinchi F,Fiorito V,et al.Heme in pathophysiology:a matter of scavenging,metabolism and trafficking across cell membranes[J].Front Pharmacol,2014,5(5):61.
5 Lawen A,Lane DJ.Mammalian iron homeostasis in health and disease:uptake,storage,transport,and molecular mechanisms of action[J].Antioxid Redox Signal,2013,18(18):2473-2507.
6 Brissot P,Deugnier Y,Guyader D,et al.Iron overload and the biliary route[J].Advances in Experimental Medicine & Biology,1994,356(356):277-283.
7 Hellstr-Lindberg E.Management of anemia associated with myelodysplastic syndrome[J].Seminars in Hematology,2005,42(2 Suppl 1):10-13.
8 Jomova K,Valko M.Advances in metal-induced oxidative stress and human disease[J].Toxicology,2011,283(2/3):65-87.
9 Zuo Y,Xiang B,Yang J,et al.Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1[J].Cell Res,2009,19(4):449-457.
10 Telfer P.Update on survival in thalassemia major[J].Hemoglobin,2009,33(Suppl1):76-80.
11 Yang JC,Robert C,Gough SM,et al.Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome[J].Leuk Res,2014,38(1):95-102.
12 Bejar R,Stevenson K,Abdelwahab O,et al.Clinical effect of point mutations in myelodysplastic syndromes[J].N Engl J Med,2011,364(26):2496-2506.
13 Pullarkat V.Objectives of iron chelation therapy in myelodysplastic syndromes:more than meets the eye?[J].Blood,2009,114(26):5251-5255.
14 Kikuchi S,Kobune M,Iyama S,et al.Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox[J].Free Radic Biol Med,2012,53(4):643-648.
15 Badawi MA,Vickars LM,Chase JM,et al.Red blood cell transfusion independence following the initiation of iron chelation therapy in myelodysplastic syndrome[J].Adv Hematol,2010,2010:1687-9104.
16 List AF,Baer MR,Steensma DP,et al.Deferasirox reduces serum ferritin and labile plasma iron in RBC transfusion-dependent patients with myelodysplastic syndrome[J].J Clin Oncol,2012,30(17):2134-2139.
17 Baldomero H,Gratwohl M,Gratwohl A,et al.The EBMT activity survey 2009:trends over the past 5 years[J].Bone Marrow Transplantation,2011,46(4):485-501.
18 Gaziev J,Sodani P,Polchi P,et al.Bone marrow transplantation in adults with thalassemia:treatment and long-term follow-up[J].Ann N Y Acad Sci,2005,1054(1):196-205.
19 Kanda J,Mizumoto C,Ichinohe T,et al.Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation[J].Bone Marrow Transplantation,2011,46(2):208-216.
20 Armand P,Kim HT,Rhodes J,et al.Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation[J].Biol Blood Marrow Transplant,2011,17(6):852-860.
21 Wermke M,Schmidt A,Middeke JM,et al.MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation[J].Clin Cancer Res,2012,18(23):6460-6468.
22 Maradei S C,Maiolino A,de Azevedo A M,et al.Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation[J].Blood,2009,114(6):1270-1275.
23 Pullarkat V,Blanchard S,Tegtmeier B,et al.Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation[J].Bone Marrow Transplantation,2008,42(12):799-805.
24 Tachibana T,Tanaka M,Takasaki H,et al.Pretransplant serum ferritin is associated with bloodstream infections within 100 days of allogeneic stem cell transplantation for myeloid malignancies[J].Int J Hematol,2011,93(3):368-374.
25 Guo M,Song L P,Jiang Y,et al.Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms[J].Apoptosis,2006,11(1):67-77.
26 Pullarkat V,Sehgal A,Liang L,et al.Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors[J].Leuk Res,2012,36(8):966-973.
27 Roth M,Will B,Simkin G,et al.Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation[J].Blood,2012,120(2):386-394.
28 Fukushima T,Kawabata H,Nakamura T,et al.Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia[J].Anticancer Res,2011,31(5):1741-1744.
29 Yamasaki T,Terai S,Sakaida I.Deferoxamine for advanced hepatocellular carcinoma[J].N Engl J Med,2011,365(6):576-578.
30 Kaloyannidis P,Yannaki E,Sakellari I,et al.The impact of desferrioxamine postallogeneic hematopoietic cell transplantation in relapse incidence and disease-free survival:a retrospective analysis[J].Transplantation,2010,89(4):472-479.
31 Michallet M,Sobh M,Morisset S,et al.Significant impact of iron chelation after allogeneic hematopoetic stem cell transplantation on disease recurrence:potential anti-leukemic activity[J].Blood,2013,122(21):180.
32 Greenberg PL,Attar E,Bennett JM,et al.NCCN clinical practice guidelines in oncology:myelodysplastic syndromes[J].J Natl Compr Canc Netw,2011,9(1):30-56.
33 Meynard D,Babitt JL,Lin HY.The liver:conductor of systemic iron balance[J].Blood,2013,123(2):168-176.
34 Oshrine B,Lehmann LE,Duncan CN.Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation[J].J Pediatr Hematol Oncol,2011,33(3):92-97.
35 Kikuchi S,Kobune M,Iyama S,et al.Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox[J].Free Radic Biol Med,2012,53(4):643-648.

[1]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[2]	FENG Yue,XING Linan,WANG Zhao,ZHANG Yunyan. Correlation between NLR and prognosis of concurrent chemoradiotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 284-288.
[3]	BAI Xiaobin, HUO Longwei, XIE Wanfu, XU Gaofeng, WANG Maode. Expression of Chk1 in glioblastoma and its association with tumor biological behavior and prognosis survival [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 122-127.
[4]	SHI Xiaokang, DING Youming, WANG Bin, YU Bin, XU Yu. Expression and clinical significance of UBE2T in primary liver cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 128-133.
[5]	LU Jiaoyun, ZHANG Qingyuan. Advances in laboratory markers in the prognosis of diffuse large B-cell lymphoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 183-187.
[6]	ZHAO Fengjuan, WANG Qi, REN Yunhong, WEI Jueling, LI Lequn, ZHAO Xinhua, TANG Juan, YOU Xuemei. Changes of serum CRP and hs-CRP levels in patients with liver cancer and depression and their influence on prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 27-33.
[7]	ZHANG Fengchun, JIANG Ying, LIU Zhaonan, YAN Ningning, CUI Hongquan, XU Yingchun. Prognostic significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in systemic inflammation-related indicators in gastric cancer patients after radical resection [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 34-39.
[8]	MA Jianli, ZHANG Minghui, JI Hongfei, XU Xiangying. Clinical significance of combined detection of PD-L1 protein and CD8⁺TILs in resected lung adenocarcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 40-46.
[9]	YANG Hongbo, SHI Jie, YE Yong, LI Wencheng, DENG Zhaoping. Expression of COL5A2 in bladder cancer tissues and its correlation with clinicopathological features and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 52-56.
[10]	WANG Yalong, LYU Zhangyan, ZHANG Fan, FENG Xiaoshuang, WEI Luopei, LI Xin, WEN Yan, GAO Yushun, XUE Qi, GAO Shugeng, TAN Fengwei. Relationship between human papillomavirus infection and prognosis of lung cancer:A meta-analysis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 520-526.
[11]	TANG Shuli, HE Kuangbang, ZHANG Chunhui, CHENG Jianan, ZHANG Yanqiao. Expression of miR-320a and CYLD in gastric cancer and its relationship with clinicopathological characteristics and prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 538-544.
[12]	XIAO Hongwei, CHEN Sheng, WANG Yanliang, SU Xueliang. The prognostic and influence factors analysis of transanal local resection for stage T₁ rectal cancer with the distance from anal margin ≤8 cm [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 545-549.
[13]	WANG Yiran, HUANG Wei, YIN Lei, LIU Lin, ZHOU Xiaoping, NIU Xingjian, YANG Yue, AN Weiwei, JI Hongfei. The ratio of neutrophil to lymphocyte in the efficacy and prognosis of concurrent chemoradiotherapy in patients with cervical cancer and its clinical significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 404-409.
[14]	LI Meiyan, CHEN Yongxue, HOU Junde. Effects of Leptin,VEGF and different anesthesia methods on prognosis of endometrial cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 426-431.
[15]	HAN Teng, TANG Liping. Advances in the relationship between the PD-L1 expression and the prognosis of gynecologic malignancies [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 468-470.

The research progress in transfusion-related iron overload in hematological malignancies

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments