PRACTICAL ONCOLOGY JOURNAL ›› 2019, Vol. 33 ›› Issue (2): 160-166.doi: 10.11904/j.issn.1002-3070.2019.02.012

• Clinical Application • Previous Articles     Next Articles

Comparison of 18F-FDG PET/CT imaging IHP,Deauville and △SUVmax image analysis methods in the evaluation of the early and mid-stage treatment sensitivity and prognosis in malignant lymphoma

LI Xuerong1, 2, FENG Hongyan1, 2, ZHOU Ying1, 2, LI Chaoqun1, 2, LAN Xiaoli3, BU Lihong1, 2   

  1. 1.The Center of PET, Renmin Hospital of Wuhan University, Wuhan 430060, China;
    2.The Center of Molecular Imaging, Renmin Hospital of Wuhan University;
    3.Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Received:2018-12-12 Revised:2019-01-22 Online:2019-04-20 Published:2019-04-25

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Abstract: Objective The aim of this study was to explore the values of IHP standard visual judgment,deauville(5-porint scoring and 5-PS)and maximum standard uptake rate(△SUVmax)image methods in the evaluation of early-and mid-term sensitivity determination and prognosis in malignant lymphoma patients. Methods A total of 51 patients with lymphoma who met the inclusion criteria were selected for retrospectively analyses.PET/CT images of patients were analyzed by IHP standard visual judgment and deauville five-point methods.The △SUVmax value of the patient in the early and middle stages of treatment was calculated before treatment, and the optimal cut-off value of PET/CT for early- and mid-term sensitivity determination and prognosis of evaluation △SUVmax was obtained by ROC curve.The differences between the diagnostic efficiencies of three methods were compared.The Kaplan-Meier analysis and Cox proportional hazard regression model were used for univariate and multivariate analyses. Results The results of ROC curve analysis showed that PET/CT had the best diagnostic efficiency when △SUVmax was 56.95%.IHP standard visual judgment,deauville quintile and △SUVmax methods could obtain high sensitivity and negative predictive values for the early-term treatment of lymphoma treatment.The positive predictive values and accuracy of △SUVmax method were higher than other two methods. Conclusion IHP standard visual judgment,deauville 5,and △SUVmax have high clinical values in the evaluation of early and middle stage of lymphoma treatment and prognosis.They can be used as independent risk factors for prognosis.

Key words: Lymphoma, 18F-FDG PET/CT, IHP, Deauville 5-point Scoring, △SUVmax

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