Journal of Practical Oncology ›› 2020, Vol. 34 ›› Issue (3): 254-257.doi: 10.11904/j.issn.1002-3070.2020.03.012

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Research progress of diallyltrisulfide in inhibiting proliferation of digestive tract tumor cells

WANG Haoran1,ZHANG Ling2   

  1. 1.Department of Gastroenterology,Clinical College of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;
    2.Department of Gastroenterology,Baotou Central Hospital,Inner Mongolia Autonomous Region
  • Received:2019-11-13 Revised:2019-12-30 Published:2020-06-30

Abstract: Diallyltrisulfide is a unique component of a sulfur-containing compound in garlic,and it is a complex of multiple sulfur-containing compounds.Studies have shown that diallyltrisulfide can inhibit the proliferation of a variety of tumor cells.In recent years,many studies have attracted much attention on the inhibitory effect of diallyltrisulfide on proliferation of digestive tract tumor cells.A large number of studies have shown that diallyltrisulfide can inhibit the growth of esophageal cancer,gastric cancer,liver cancer,pancreatic cancer and colon cancer cells,and its mechanism of action is related to affecting cell signal transduction,inhibiting cell growth and inducing apoptosis.The mechanism of diallyltrisulfide inhibiting the proliferation of gastrointestinal tumor cells is a more complicated cell biological process,and the specific mechanism has not yet been fully clarified at present.Therefore,this paper briefly reviews the relevant research progress of the mechanism of diallyltrisulfide inhibiting proliferation of gastrointestinal tumor cells.

Key words: Diallyltrisulfide, Digestive tract tumor, Inhibitory effect

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