Abstract: Pancreatic cancer is a highly lethal malignant tumor with a 5-year survival rate less than 8%.The prognosis of patients with pancreatic cancer who can undergo radical surgery is significantly different from that of those who have not undergone surgery.Simple surgical treatment can only increase the 5-year survival rate of pancreatic cancer to about 10%.The main reason is that the recurrence and metastasis rates are still extremely high after surgery alone,and the quality of patient life with recurrence and metastasis is poor,their prognosis is extremely poor,and the long-term survival time is short.Therefore,it is of great significance to seek more effective adjuvant therapy or regimen for pancreatic cancer surgery,and to carry out standardized,rational and comprehensive drug therapy,to control micrometastasis,and to prevent and delay recurrence.This research field is also the focus on research direction about pancreatic cancer in recent years.This article is based on the recent research and development of postoperative treatment of pancreatic cancer,exploring survival benefit of different drugs and different treatment options after pancreatic cancer surgery and the development trend of postoperative treatment of pancreatic cancer,providing a valuable reference for postoperative treatment of pancreatic cancer.

Key words: Postoperative adjuvant therapy, Pancreatic cancer, Chemo-therapy, Targeted therapy, Immuno-therapy