Journal of Practical Oncology ›› 2021, Vol. 35 ›› Issue (4): 365-369.doi: 10.11904/j.issn.1002-3070.2021.04.013

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A systematic review of simvastatin in the treatment of colorectal cancer

HUANG Rui, LIU Chao, ZHANG Yanqiao   

  1. Harbin Medical University Cancer Hospital,Harbin 150081,China
  • Received:2020-06-20 Revised:2020-10-21 Published:2021-08-24

Abstract: “Drug reuse” or “drug relocation” is a hot topic in the field of oncology.It refers to finding a marketed drug with anticancer activity that is not a cancer indication,and combining it with conventional cancer treatments with a view to bringing survival benefits to patients.Simvastatin is commonly used clinically to treat hyperlipidemia and prevent cardiovascular diseases.Many studies have found that simvastatin has great potential for the treatment of colorectal cancer.Many clinical studies have tried to use simvastatin as an adjuvant drug for the treatment of metastatic colorectal cancer.

Key words: Colorectal cancer, Simvastatin, Drug reuse, Drug relocation

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