ILF2及NF90在口腔鳞状细胞癌中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2022.02.007

Abstract

Abstract: Objective The aim of this study was to investigate the expression of interleukin enhancer binding factor 2(ILF2)and nuclear factor 90(NF90)in oral squamous cell carcinoma(OSCC)and their clinical significance.Methods Immunohistochemistry(IHC)and quantitative real-time PCR(qRT-PCR)were used to detect the expression of ILF2 and NF90 in OSCC and normal oral mucosa(NOM)tissues.The relationship between their expression and clinicopathological features and prognosis of OSCC patients was further analyzed.Oncomine and GEPIA databases were used to analyze their expression in different tissues.Results Compared with NOM tissues,ILF2 and NF90 were highly expressed in OSCC tissues(P＜0.05);their expression was positively correlated in OSCC tissues(φ=0.540,P＜0.001);the results of Oncomine database showed that ILF2 and NF90 were also highly expressed in OSCC tissues(P＜0.05);The results of GEPIA database showed that the expression of ILF2 and NF90 in OSCC was positively correlated(r=0.600,P＜0.001).The expression of ILF2 and NF90 was correlated with the degree of tumor differentiation,TNM stage and lymph node metastasis of OSCC(P＜0.05).Prognostic survival analysis showed that patients with high expression of ILF2 and NF90 had a short overall survival,and the high expression of ILF2 and NF90 and the degree of tumor differentiation were independent risk factors affecting the overall survival of patients.Conclusion ILF2 and NF90 are highly expressed and correlated in OSCC,and they are correlated,and have adverse effects on the prognosis of OSCC patients,suggesting that they can be used as new diagnostic markers and prognostic indicators for the occurrence and development of OSCC

Key words: Oral squamous cell carcinoma, Leukocytokinin enhancing binding factor 2, Nuclear factor 90

CLC Number:

R782

WANG Xue, GAO Yuwei, SONG Hongquan, ZHANG Xingwei, YANG Fan, JIAO Xiaohui. Expression and clinical significance of ILF2 and NF90 in oral squamous cell carcinoma[J]. Journal of Practical Oncology, 2022, 36(2): 137-143.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.02.007

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I2/137

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Expression and clinical significance of ILF2 and NF90 in oral squamous cell carcinoma

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