基于铁死亡的纳米联合疗法在恶性肿瘤治疗中的研究进展

doi:10.11904/j.issn.1002-3070.2022.05.007

Abstract

Abstract: As a potential treatment strategy for malignant tumors,ferroptosis has attracted widespread attention.Ferroptosis is an iron-dependent regulatory cell death that is typically characterized by the accumulation of intracellular reactive oxygen species and lipid peroxidation.With the rapid development of nanotechnology and biomaterial technology,multifunctional nanoformulation-mediated ferroptosis combined therapy shows great clinical application prospects in tumor diagnosis and treatment.This article reviews the mechanism of nano-formulation-induced ferroptosis and the latest research progress of ferroptosis-based combined antitumor therapy,and summarizes the application prospects and challenges of ferroptosis in clinical tumor treatment,expecting new ideas for tumor strategies to develop new and efficient anti-cancer drugs.

Key words: Ferroptosis, Malignant tumor, Nanomaterials, Combination therapy

CLC Number:

R914

WANG Qin, LIU Junjie, LU Xiuxin, WU Yafei, ZHANG Wenhao. Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors[J]. Journal of Practical Oncology, 2022, 36(5): 429-434.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.05.007

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I5/429

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Research progress of nanocombination therapy based on ferroptosis in the treatment of malignant tumors

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