小肠肿瘤罕见原因

doi:10.11904/j.issn.1002-3070.2022.06.007

Abstract

Abstract: The small intestine is the longest section of the digestive tract,and it is the main place for food digestion,absorption and energy conversion.However,there are few reports on the small intestine tumors.Primary malignant tumors of the small intestine are rare in clinical practice.Due to the lack of typical clinical manifestations and effective treatment methods,the prognosis is extremely poor.The large surface area of the small intestine and the state of rapid epithelial renewal clearly contradict the low incidence of tumors.The scientific problem about the lower incidence of small tumors has become a century-old mystery that plagues the field of medical science.This review mainly analyzes the reasons for the rareness of small intestinal tumors from four aspects:the unique physiological barrier of the small intestine,gene regulatory system,commensal flora and mucosal immune system.Understanding the precise regulatory mechanism of the small intestine will provide new ideas for further studies of aging,gut microbiota,and cancer prevention and treatment.Based on previous studies and the latest research progress,this article reviews the epidemiological status of small intestine tumors,the possible reasons for the low incidence,and their implications for tumor prevention and treatment.

Key words: Small intestine, Tumor, Genetics, Microorganism, Immunity

CLC Number:

R735.3⁺2

NA Ruisi, GUO Ying, SHI Jiaqi, ZHENG Tongsen. Reasons why small intestinal tunors are rare[J]. Journal of Practical Oncology, 2022, 36(6): 526-530.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I6/526

References

1 Barlow JT,Leite G,Romano AE,et al.Quantitative sequencing clarifies the role of disruptor taxa,oral microbiota,and strict anaerobes in the human small-intestine microbiome[J].Microbiome,2021,9(1):1-17.
2 Pan SY,Morrison H.Epidemiology of cancer of the small intestine[J].World J Gastrointest Oncol,2011,3(3):33-42.
3 Lowenfels AB.Why are small-bowel tumours so rare?[J].Lancet,1973,1(7793):24-26.
4 Calman KC.Why are small bowel tumours rare? An experimental model[J].Gut,1974,15(7):552-554.
5 Gelsomino F,Balsano R,De Lorenzo S,et al.Small bowel adenocarcinoma:from molecular insights to clinical management[J].Curr Oncol,2022,29(2):1223-1236.
6 Ocasio Quinones GA,Khan Suheb MZ,Woolf A.Small bowel cancer[M].Treasure Island(FL):StatPearls,2022.
7 Safatle-Ribeiro AV,Ribeiro UJr.Impact of enteroscopy on diagnosis and management of small bowel tumors[J].Chin J Cancer Res,2020,32(3):319-333.
8 Puccini A,Battaglin F,Lenz HJ.Management of advanced small bowel cancer[J].Curr Treat Options Oncol,2018,19(12):69.
9 Le DT,Durham JN,Smith KN,et al.Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade[J].Science,2017,357(6349):409-413.
10 Emilsson L,Semrad C,Lebwohl B,et al.Risk of small bowel adenocarcinoma,adenomas,and carcinoids in a nationwide cohort of individuals with celiac disease[J].Gastroenterology,2020,159(5):1686-1694.
11 Latham A,Shia J,Patel Z,et al.Characterization and clinical outcomes of DNA mismatch repair-deficient small bowel adenocarcinoma[J].Clin Cancer Res,2021,27(5):1429-1437.
12 Deloose E,Janssen P,Depoortere I,et al.The migrating motor complex:control mechanisms and its role in health and disease[J].Nat Rev Gastroenterol Hepatol,2012,9(5):271-285.
13 Donaldson GP,Lee SM,Mazmanian SK.Gut biogeography of the bacterial microbiota[J].Nat Rev Microbiol,2016,14(1):20-32.
14 Bottcher A,Buttner M,Tritschler S,et al.Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates[J].Nat Cell Biol,2021,23(1):23-31.
15 Riva L,Pandiri AR,Li YR,et al.The mutational signature profile of known and suspected human carcinogens in mice[J].Nat Genet,2020,52(11):1189-1197.
16 Martincorena I,Raine KM,Gerstung M,et al.Universal patterns of selection in cancer and somatic tissues[J].Cell,2018,173(7):1823.
17 Cairns J.Mutation selection and the natural history of cancer[J].Nature,1975,255(5505):197-200.
18 Potten CS.Stem cells in gastrointestinal epithelium:numbers,characteristics and death[J].Philos Trans R Soc Lond B Biol Sci,1998,353(1370):821-830.
19 Koren E,Yosefzon Y,Ankawa R,et al.ARTS mediates apoptosis and regeneration of the intestinal stem cell niche[J].Nat Commun,2018,9(1):1-17.
20 Schepers AG,Vries R,Van Den Born M,et al.Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes[J].EMBO J,2011,30(6):1104-1109.
21 Tomasetti C,Vogelstein B.Cancer etiology.Variation in cancer risk among tissues can be explained by the number of stem cell divisions[J].Science,2015,347(6217):78-81.
22 Ogata M,Oomori T,Soga H,et al.DNA repair after DNA fragmentation in mouse small intestinal epithelial cells[J].Cell Tissue Res,2009,335(2):371-382.
23 Schrock AB,Devoe CE,Mcwilliams R,et al.Genomic profiling of small-bowel adenocarcinoma[J].JAMA Oncol,2017,3(11):1546-1553.
24 Kadosh E,Snir-Alkalay I,Venkatachalam A,et al.The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic[J].Nature,2020,586(7827):133-138.
25 Mantovani F,Collavin L,Del Sal G.Mutant p53 as a guardian of the cancer cell[J].Cell Death Differ,2019,26(2):199-212.
26 Ocvirk S,O'keefe SJD.Dietary fat,bile acid metabolism and colorectal cancer[J].Semin Cancer Biol,2021,73:347-355.
27 Mohammed AD,Mohammed Z,Roland MM,et al.Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel[J].Nat Commun,2022,13(1):1-17.
28 Roberti MP,Yonekura S,Duong CPM,et al.Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer[J].Nat Med,2020,26(6):919-931.
29 Daillere R,Vetizou M,Waldschmitt N,et al.Enterococcus hirae and barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects[J].Immunity,2016,45(4):931-943.
30 Zhang P,Liu J,Xiong B,et al.Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis[J].Microbiome,2020,8(1):1-15.
31 Song M,Chan AT,Sun J.Influence of the gut microbiome,diet,and environment on risk of colorectal cancer[J].Gastroenterology,2020,158(2):322-340.
32 Fawkner-Corbett D,Antanaviciute A,Parikh K,et al.Spatiotemporal analysis of human intestinal development at single-cell resolution[J].Cell,2021,184(3):810-826.
33 Rios D,Wood MB,Li J,et al.Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria[J].Mucosal Immunol,2016,9(4):907-916.
34 Chen H,Zhang Y,Ye AY,et al.BCR selection and affinity maturation in Peyer's patch germinal centres[J].Nature,2020,582(7812):421-425.
35 Fenton TM,Jorgensen PB,Niss K,et al.Immune profiling of human gut-associated lymphoid tissue identifies a role for isolated lymphoid follicles in priming of region-specific immunity[J].Immunity,2020,52(3):557-570.
36 Simoni Y,Fehlings M,Kloverpris HN,et al.Human innate lymphoid cell subsets possess tissue-type based heterogeneity in phenotype and frequency[J].Immunity,2017,46(1):148-161.
37 Olivares-Villagomez D,Van Kaer L.Intestinal intraepithelial lymphocytes:sentinels of the mucosal barrier[J].Trends Immunol,2018,39(4):264-275.
38 Mayassi T,Jabri B.Human intraepithelial lymphocytes[J].Mucosal Immunol,2018,11(5):1281-1289.
39 Morikawa R,Nemoto Y,Yonemoto Y,et al.Intraepithelial lymphocytes suppress intestinal tumor growth by cell-to-cell contact via CD103/E-Cadherin signal[J].Cell Mol Gastroenterol Hepatol,2021,11(5):1483-1503.
40 Biton M,Haber AL,Rogel N,et al.T helper cell cytokines modulate intestinal stem cell renewal and differentiation[J].Cell,2018,175(5):1307-1320.
41 Gronke K,Hernandez PP,Zimmermann J,et al.Interleukin-22 protects intestinal stem cells against genotoxic stress[J].Nature,2019,566(7743):249-253.
42 Lee JW,Epardaud M,Sun J,et al.Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self[J].Nat Immunol,2007,8(2):181-190.
43 Mohammed AD,Mohammed Z,Roland MM,et al.Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel[J].Nat Commun,2022,13(1):525.
44 Di Micco R,Krizhanovsky V,Baker D,et al.Cellular senescence in ageing:from mechanisms to therapeutic opportunities[J].Nat Rev Mol Cell Biol,2021,22(2):75-95.
45 Brooks JF 2nd,Behrendt CL,Ruhn KA,et al.The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock[J].Cell,2021,184(16):4154-4167.
46 Sbierski-Kind J,Grenkowitz S,Schlickeiser S,et al.Effects of caloric restriction on the gut microbiome are linked with immune senescence[J].Microbiome,2022,10(1):1-21.
47 Fu A,Yao B,Dong T,et al.Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer[J].Cell,2022,185(8):1356-1372.
48 Guo W,Zhang C,Wang X,et al.Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing[J].JCI Insight,2022,7(1):1-18.

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Reasons why small intestinal tunors are rare

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