Abstract: Objective This study aimed to study the incidence time trend and survival analysis of thyroid cancer among residents in Cangzhou urban area from 2010 to 2019,so as to provide reference for the prevention and treatment of thyroid cancer in Cangzhou urban area. Methods The surveillance data of thyroid cancer incidence in Cangzhou urban area from 2010 to 2019 were collected,and the incidence,age-standardized rate,annual percentage change in incidence(APC),average survival time and cumulative survival rate of thyroid cancer were analyzed. Results The average annual incidence of thyroid cancer in Cangzhou urban area from 2010 to 2019 was 18.64/100,000,and the China standardized rate was 17.60/100,000.The incidence in female was higher than that in male(P＜0.05).The incidence increased rapidly in the 20-year-old group,reaching the peak in the 50-year-old group,and then the incidence gradually decreased with the increase of age.The incidence of thyroid cancer showed an upward trend from 2010 to 2014(APC=41.95%,95% CI:3.68%-94.35%,P=0.035).The average survival time of thyroid cancer patients was 124.29 months,and the 5-year and 10-year cumulative survival rates were 93.2% and 90.4%,respectively.There was no statistical difference in the survival curve between different genders(P＞0.05),and the survival status of thyroid cancer in the group of patients under 65 years old was better than that in the group of patients aged 65 and above.(P＜0.05). Conclusion Thyroid cancer has a growing threat to the health of residents in Cangzhou urban area.The population′s disease and economic burden of residents caused by thyroid cancer should be taken to reduce through comprehensive intervention measures.

Key words: Thyroid cancer, Incidence, Annual percentage change, Time trend analysis, Survival analysis