Abstract: Objective The aim of this study was to explore the evaluation values of dynamic contrast-enhanced and diffusion-weighted imaging(DWI)of three-dimensional volume interpolated body examination(3D VIBE)for pathological stages of endometrial carcinoma(EC). Methods A total of 224 patients with EC admitted to Haimen District People′s Hospital in Nantong city from January 2021 to January 2024 were selected for 3D VIBE dynamic enhanced scanning and DWI scanning.The consistency between the results of 3D VIBE dynamic enhanced scanning and pathological staging was analyzed,and the differences in the apparent diffusion coefficient(ADC)and relative apparent diffusion coefficient(rADC)value among EC patients with different pathological stages were compared.The evaluation values of ADC and rADC for the pathological stages of EC were analyzed. Results Among 224 patients with EC,122(54.46%)were in the stage ⅠA,39(17.41%)were in the stage ⅠB,27(12.05%)were in the stage Ⅱ,25(11.16%)were in the stage ⅢA,and 11(4.91%)were in the stage ⅢB.The sensitivity,specificity,and accuracy of 3D VIBE dynamic enhanced evaluation for stages ⅠA,ⅠB,Ⅱ,ⅢA and ⅢB were 92.62%,87.18%,85.19%,80.00%,and 81.82%,respectively,for the sensitivities,96.08%,93.51%,97.96%,98.49%,and 99.06%,respectively,for specificities,94.20%,92.41%,96.42%,96.42%,and 98.21%,respectively,for accuracies.The 3D VIBE dynamic enhancement demonstranted substantial agreement with the pathological staging of endometrial cancer(Kappa=0.829,P＜0.05).There was a statistical difference in ADC and rADC among patients with different pathological stages of EC(P＜0.05).ADC and rADC in EC patients with stages IB,Ⅱ,ⅢA and ⅢB were lower than those in EC patients with stage ⅠA(P＜0.05).ADC and rADC were lower in the stage Ⅱ,ⅢA,and ⅢB EC patients than those in the stage ⅠB,and ADC and rADC were lower in the stage ⅢB EC patients than those in the stage Ⅱ(P＜0.05).The ROC curve analysis results revealed that the AUCs of ADC and rADC in the diagnosing pathological stages(ⅠA vs. ⅠB-ⅢB、ⅠA-ⅠB vs. Ⅱ-ⅢB、ⅠA-Ⅱ vs. ⅢA-ⅢB、ⅠA-ⅢA vs. ⅢB) of EC were 0.878,0.935,0.942,0.974 and 0.935,0.962,0.954,0.955,respectively(P＜0.05). Conclusion Both 3D VIBE dynamic enhancement and DWI have good clinical application value in evaluating the pathological stages of EC,and can provide a reference for the development of diagnosis and treatment plans for EC.

Key words: Endometrial carcinoma, Pathological staging, Dynamic enhancement of three-dimensional volume interpolated body examination, Diffusion weighted imaging