Abstract: Gastric cancer,as a malignant tumor with a relatively high incidence rate worldwide,faces many challenges in its treatment.Traditional surgical treatment,chemotherapy and radiotherapy can to some extent improve the survival rate and quality of life of patients with gastric cancer,but their overall efficacy is still limited and they are often accompanied by significant side effects.In recent years,hydrogen sulfide(H₂S),as an important biogas,has shown its unique role in various biological processes,especially gradually attracting attention in the development and treatment of tumors.Studies have shown that hydrogen sulfide not only has the potential to fight tumors,but also can affect the growth,proliferation and apoptosis of tumor cells through multiple mechanisms.In addition,the combined use of hydrogen sulfide with existing treatment methods may provide a more effective treatment strategy for patients with gastric cancer.This article aims to review the potential role of hydrogen sulfide in the treatment of gastric cancer,focusing on the latest research progress in its anti-tumor mechanism,combination with traditional treatment methods,and safety.It is hoped that this will provide new ideas and directions for the future treatment of gastric cancer,promote the in-depth development of related research,and improve the prognosis and quality of life of patients with gastric cancer.

Key words: Hydrogen sulfide, Gastric cancer, Therapeutic strategies