Abstract: It has been demonstrated that astrocyte elevated gene 1(AEG-1)can promote tumor initiation and progression.Over expression of AEG-1 is correlated with tumor angiogenesis,metastasis and chemotherapy resistance of tumor cells of different origins.The present article is a review on the mechanism of AEG-1 mediated drug resistance.Studies have shown that AEG-1 participates in carcinogenesis through Ha-ras,myc,NF-κB and PI3K/Akt signalling pathways.AEG-1 can also promote autophagy through activating AMP Kinase.Other researchers demonstrate that AEG-1 promotes MDR1 protein translation by up-regulating MDR1 mRNA expression,and thus increases polyribosome.It is testified that AEG-1 can influence drug susceptibility and expression of MDR gene as a RNA binding protein.Multiple functions of AEG-1 in drug resistance in multiple cancers demonstrate that AEG-1 can be used as a novel target for antitumor drugs.