关键词: IGF-1R, IRS-1, 肺肿瘤, 鳞癌

Abstract:

Objective The aim of the study is to detect the expression of IGF-1R and IRS-1 in squamous cell lung cancer(SQCLC)and to explore the role in the development of squamous cell lung cancer and clinical significance.Methods Specimens from 246 surgical SQCLC and 40 adjacent normal lung tissues were evaluated for IGF-1R and IRS-1 expression by immunohistochemistry.We explored the correlation between IGF-1R and IRS-1,their relationship with clinicopathological parameters and their impact on outcome in SQCLC patients.Results SQCLC of IGF-1R positive expression rate was 54.07%,which was higher than in adjacent normal tissue(32.5%),SQCLC of IRS-1 positive expression rate was 38.21%,which was lower than in adjacent normal tissue(70%),the pairwise difference was statistically significant(P＜0.05);Expression of IGF-1R was correlated with lymph node metastasis(P＜0.05),IRS-1 expression was related with degree of differentiation and lymph node metastasis(P＜0.05).Survival of IGF-1R expression group of patients was significantly shorter than the expression of IGF-1R negative patients,the survival of the IRS-1 expression was significantly longer than patients who negatively expressed IRS-1,the difference was statistically significant(P=＜0.001 and =0.021).IGF-1R was negatively correlated with IRS-1 expression in SQCLC(r=-0.125,P＜0.001).Conclusion IGF-1R,IRS-1 are involved in the occurrence of SQCLC,the development.The IGF-1R is an independent prognostic factor in SQCLC.

Key words: IGF-1R, IRS-1, Lung neoplasms, Squamous cell carcinoma