细胞自噬与肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.013

摘要/Abstract

摘要： 自噬是存在于真核细胞中并具有高度保守性的生物学行为，是包裹细胞质成分的双层膜结构形成并与溶酶体结合产生自我吞噬的分解代谢过程。自噬的分解代谢作用不但可以维持细胞内环境的稳态，还和肿瘤的发生发展以及肿瘤化疗耐药密切相关。由此得知，抑制细胞自噬是对抗化疗耐药的又一崭新潜在途径，临床中应用自噬抑制剂联合化疗药物增加肿瘤药物的敏感性，并有望成为有效的肿瘤治疗策略。

关键词: 自噬, 肿瘤, 化疗耐药

Abstract: Autophagy is a highly conservative biological behavior in eukaryotic cells.This dynamic process involves "wrapping" cytoplasmic components and combining with lysosomes in cells for catabolism.Autophagy can not only take part in maintaining homeostasis,but also be closely related with tumor development and resistant.Therefore,autophagy is a potential target for antitumor drug resistant.Specific inhibition of autophagy in cancer cells combined with chemotherapy is expected to be an effective cancer treatment strategy.

Key words: Autophagy, Tumor, Chemotherapy drug resistance

中图分类号:

任婷婷，邢影，综述，孟庆威，审校. 细胞自噬与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2016, 30(6): 543-546.

REN Tingting,XING Ying,MENG Qingwei. Progress in association between autophagy and cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 543-546.

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