肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究

doi:10.11904/j.issn.1002-3070.2017.01.001

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (1): 1-6.doi: 10.11904/j.issn.1002-3070.2017.01.001

• 基础研究 • 下一篇

肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究

余长艳, 甄丽娜, 李洪滨, 张悦, 张清媛

哈尔滨医科大学附属肿瘤医院肿瘤内科(哈尔滨 150081)

收稿日期:2015-03-19 出版日期:2017-02-28 发布日期:2017-02-20
通讯作者: 张悦,E-mail:18946114826@163.com
作者简介:余长艳,女,(1991-),硕士研究生,从事免疫系统在肿瘤中功能变化解析的研究
基金资助:
黑龙江省自然科学基金(重点项目)(ZD2016018)

The correlations between expression of tumor associated macrophages and the prognostic significances in triple negative breast cancer

YU Changyan, ZHEN Lina, LI Hongbing, ZHANG Yue, ZHANG Qingyuan

Department of Medical Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-03-19 Online:2017-02-28 Published:2017-02-20

摘要/Abstract

摘要： 目的探讨肿瘤相关巨噬细胞(Tumor-associated macrophages,TAMs)在三阴性乳腺癌(Triple-negative breast cancer,TNBC)中的表达及其与临床病理因素和预后的关系。方法应用免疫组化染色法检测108例TNBC组织中TAMs的表达情况,同时检测癌组织中微血管密度(Microvessel density,MVD),分析TAMs表达与TNBC临床病理参数、MVD及预后的关系。结果 TAMs表达与患者年龄无关,与肿瘤大小、淋巴结转移、组织学分级、TNM分期及MVD密切相关。生存分析显示TAMs与TNBC术后5年无病生存时间(Disease-free survival,DFS)及总生存时间(Overall survival,OS)相关;MVD与5年DFS相关,而与OS未见相关性。Cox回归分析示TAMs是TNBC预后不良的独立危险因素。结论 TAMs高表达提示TNBC预后不良,TAMs可成为判断预后的免疫指标之一。TAMs与MVD密切相关,可能通过促进瘤内血管增生,从而促进TNBC的生长、侵袭和转移,进一步影响TNBC患者的预后。

关键词: 三阴性乳腺癌, 肿瘤相关巨噬细胞, 微血管密度, 预后

Abstract: Objective To explore the significances of expression of tumor associated macrophages(TAMs)and its correlation with microvessel density(MVD)in triple negative breast cancer(TNBC).Methods Immunohistochemistry was used to detect TAMs and MVD expression in 108 TNBC tissues and to analyze the correlation between TAMs with clinicopathological features,prognosis and MVD.Results The expression of TAMs was correlated with the tumor size,lymph node metastasis,histological grade,TNM stage and MVD,but had no statistically significant association with age.TAMs was correlated with 5 year disease free survival(DFS)and overall survival(OS);MVD was correlated with 5 year DFS,while no correlation with OS.Univariate and multivariate analyses showed that TAMs was an independent unfavorable prognostic factor for patients with TNBC.Conclusion High infiltration of TAMs indicated poor survival rate for patients with TNBC.The infiltration of TAMs was a new,important risk factor for TNBC recurrence.TAMs were closely related to MVD,by promoting tumor angiogenesis,thereby promoting TNBC growth,invasion and metastasis,and further affect the prognosis of patients with TNBC.

Key words: Triple negative breast cancer, Tumor associated macrophages, Microvessel density, Prognosis

中图分类号:

R737.9

余长艳, 甄丽娜, 李洪滨, 张悦, 张清媛. 肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究[J]. 实用肿瘤学杂志, 2017, 31(1): 1-6.

YU Changyan, ZHEN Lina, LI Hongbing, ZHANG Yue, ZHANG Qingyuan. The correlations between expression of tumor associated macrophages and the prognostic significances in triple negative breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 1-6.

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肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究

The correlations between expression of tumor associated macrophages and the prognostic significances in triple negative breast cancer

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