中性粒细胞与恶性肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2018.04.013

实用肿瘤学杂志 ›› 2018, Vol. 32 ›› Issue (4): 349-352.doi: 10.11904/j.issn.1002-3070.2018.04.013

中性粒细胞与恶性肿瘤关系的研究进展

韩帮岭, 汪亦民综述, 薛英威审校

哈尔滨医科大学附属肿瘤医院胃肠外科(哈尔滨 150081)

收稿日期:2018-03-05 出版日期:2018-08-20 发布日期:2018-09-06
通讯作者: 薛英威,E-mail:xyw801@163.com
作者简介:韩帮岭,男,(1991-),硕士研究生,从事胃癌临床治疗的研究。
基金资助:
哈尔滨市科技局应用技术研究与开发项目(编号:2017RAXXJ054)

Research progress in the relationship between neutrophils and malignant tumors

HAN Bangling,WANG Yimin,XUE Yingwei

Department of Gastrointestinal Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2018-03-05 Online:2018-08-20 Published:2018-09-06

摘要/Abstract

摘要： 近年来一些研究探讨了中性粒细胞在癌症中的调控功能,并阐明了其微妙的平衡。中性粒细胞通过微环境相关的方式发挥促肿瘤或抗肿瘤的作用,其是否促进或限制肿瘤的生长、发展及转移取决于中性粒细胞表面上大量的细胞因子受体,从而对各种信号作出反应。本文对不同角色的中性粒细胞在肿瘤中发挥的不同作用做一综述,探讨治疗恶性肿瘤的中性粒细胞水平潜在的治疗靶点,加强中性粒细胞的抗肿瘤活性,同时限制其促肿瘤特性,为肿瘤临床治疗提供新的思路。

关键词: 中性粒细胞, 恶性肿瘤, 微环境, 细胞因子

Abstract: In recent years,some studies have demonstrated how neutrophil function is regulated in cancer and elucidate the delicate balance.Neutrophils express tumor-promoting or anti-tumor properties in a microenvironment related manner.Whether or not they promote or limit tumor growth,development and metastasis depends on the large number of cytokine receptors on the surface of neutrophils.It can respond to various signals.This review summarizes the different effects on different roles of neutrophils in tumors,identifying potential therapeutic targets for the treatment of neutrophils at malignant neoplasms,strengthening the anti-tumor activity of neutrophils and limiting their promotion of tumorigenesis.These characteristics provide a new idea for the clinical treatment of tumors.

Key words: Neutrophils, Malignant tumor, Microenvironment, Cytokines

中图分类号:

韩帮岭, 汪亦民, 薛英威. 中性粒细胞与恶性肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 349-352.

HAN Bangling,WANG Yimin,XUE Yingwei. Research progress in the relationship between neutrophils and malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 349-352.

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中性粒细胞与恶性肿瘤关系的研究进展

Research progress in the relationship between neutrophils and malignant tumors

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