实用肿瘤学杂志 ›› 2011, Vol. 25 ›› Issue (2): 145-148.doi: 10.3969/j.issn.1002-3070.2011.02.011

• 论著 • 上一篇    下一篇

原发性肺淋巴瘤15例临床分析

徐珊琦, 张清媛, 汤大北, 张明辉   

  1. 哈尔滨医科大学附属第三医院内三科(哈尔滨 150081)
  • 收稿日期:2011-03-03 出版日期:2011-02-25 发布日期:2012-02-21
  • 通讯作者: 张清媛,E-mail:zhma19650210@163.com
  • 作者简介:徐珊琦,女,(1983-),硕士,从事淋巴瘤及乳腺癌的临床和基础研究

Clinical Analysis of 15 cases of primary pulmonary lymphoma

XU Shanqi, ZHANG Qingyuan, TANG Dabei, ZHANG Minghui   

  1. Department of Internal Medicine,the Third Affiliated Hospital of Harbin Medical University,Harbin,150081
  • Received:2011-03-03 Online:2011-02-25 Published:2012-02-21

摘要: 目的 探讨原发性肺淋巴瘤的发病情况、临床特点、诊断治疗及预后情况。方法 回顾性分析1995年1月—2008年1月哈尔滨医科大学附属第三医院收治的15例原发性肺淋巴瘤的临床资料及随访结果。结果 本组15例病例占同期收治恶性淋巴瘤患者的0.6%。其中Ⅰ~Ⅱ期患者12例,占所有病例80%;Ⅲ~Ⅳ患者3例,占20%。1年生存率和5年生存率分别为80.0%和46.7%。治疗手段以手术及全身化疗为主,早期患者预后较好。结论 原发性肺淋巴瘤发病率较低,属罕见的结外器官淋巴瘤。临床表现多样且无特异性,因而易误诊。影像学表现具有一定特性,手术及CT引导下穿刺取病理并配合免疫组化检查是主要明确该疾病的诊断方法。手术治疗组优于非手术组,预后相对较好。

Abstract: Objective To study the incidence,clinical features,diagnosis,treatment and prognosis of primary pulmonary lymphoma(PPL).Methods The clinical data of PPL patients treated in our hospital from January 1995 to January 2008 were retrospectively analyzed.Results 15 patients were diagnosed with PPL,accounted for 0.6% during the same period(15/2537).The advanced stage(stage Ⅲ and Ⅳ)patients accounted for 20%(3 cases).The 1-year overall survival and 5-year overall survival were 80.0% and 46.7% respectively.Surgical operation and chemotherapy were the major effective therapeutic approach for the treatment of PPL.Prognosis was favorable in patients with early stage of the tumor.Conclusion PPL is clinically rare and absence of typical clinicopathological characteristics,so its preoperatively exact diagnosis is difficult.Some specific imaging findings are helpful in the diagnosis of PPL.Final diagnosis of PPL could be made when a CT guided biopsy was done,followed by pathological examination with immunohistological study,or study of the tumor after surgery.The prognosis of patients received surgical operation is relatively better.

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