实用肿瘤学杂志 ›› 2009, Vol. 23 ›› Issue (1): 38-41.

• 论著 • 上一篇    下一篇

APRIL和Reg Ⅳ在卵巢癌中的表达及意义

秦誉   

  1. 哈尔滨医科大学附属肿瘤医院病理科(哈尔滨 150081)
  • 收稿日期:2008-10-07 出版日期:2009-01-20 发布日期:2012-02-21
  • 作者简介:秦誉, 男, (1980-), 硕士研究生, 住院医师, 从事肿瘤病理侵袭与转移的研究

Expressions of APRIL and Reg Ⅳ in human ovarian carcinoma and their significances

Q   

  1. Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081
  • Received:2008-10-07 Online:2009-01-20 Published:2012-02-21

摘要: 目的检测APRIL和Reg Ⅳ在卵巢肿瘤和正常组织中的表达情况及其临床意义。方法 采用免疫组化染色, 光镜观察结果确定APRIL和Reg Ⅳ在良性、交界性及恶性上皮性卵巢肿瘤组织中的表达, 并结合临床病理资料进行分析。结果 在良性、交界性及恶性上皮性卵巢肿瘤组织中皆有APRIL和Reg Ⅳ的表达, 但卵巢癌组织中的表达明显高于良性及交界性肿瘤, 其表达强度与淋巴结转移、病理类型、病理分级、年龄等无关。相关分析表明APRIL和Reg Ⅳ的表达呈正相关。结论 APRIL和Reg Ⅳ基因与癌组织的发生和进展密切相关。细胞的增殖和机体的免疫调控以及凋亡途径有着密切联系。

Abstract: Objective To investigate the expressions of APRIL and Reg Ⅳ in human ovarian tumors and their significances.Methods The expressions of APRIL and Reg Ⅳ in benign, borderline and malignant epithelial ovarian tumors were detected by immunohistochemistry and light microscopy.Results The expressions of APRIL and Reg Ⅳ were found in benign, borderline and malignant epithelial ovarian tumors.The expressions of APRIL and Reg Ⅳ in ovarian carcinomas were significantly higher than those in benign and borderline ovarian tumors.The expression levels of APRIL and Reg Ⅳ were not correlated with lymph node metastasis, histology type and age.The Spearman correlation analysis suggested that the espression of APRIL and Reg Ⅳ was positively correlated.Conclusion APRIL and Reg Ⅳ may play important roles in the carcinogenesis and progression of ovarian carcinoma.Cell proliferation is closely linked with immune regulation and apoptosis pathway.

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