卵巢癌对富脂大网膜的器官趋向性转移的研究进展

doi:10.11904/j.issn.1002-3070.2022.01.010

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (1): 54-58.doi: 10.11904/j.issn.1002-3070.2022.01.010

卵巢癌对富脂大网膜的器官趋向性转移的研究进展

董丽娜¹, 梁田¹, 张献² 综述, 张广美¹ 审校

1.哈尔滨医科大学附属第一医院妇产科(哈尔滨 150001);
2.黑龙江中医药大学

收稿日期:2021-02-01 修回日期:2021-03-03 出版日期:2022-02-28 发布日期:2022-01-21
通讯作者: 张广美,E-mail:guangmei_zhang@126.com
作者简介:董丽娜,女,(1983-),硕士,主治医师,从事妇产科超声及卵巢癌肿瘤微环境相关的研究。
基金资助:
国家自然科学基金(编号:81772780);哈尔滨医科大学创新科学研究资助项目-医学临床青年科学研究专项(编号:2018-KYYWF-0472)

Research progress on tropism of ovarian cancer to fat-rich omentum organs

DONG Lina¹, LIANG Tian¹, ZHANG Xian², ZHANG Guangmei¹

1. Department of Gynecology and Obstetrics,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;
2. Heilongjiang University of Chinese Medicine

Received:2021-02-01 Revised:2021-03-03 Online:2022-02-28 Published:2022-01-21

摘要/Abstract

摘要： 肿瘤转移是一个复杂的多步骤过程,涉及到肿瘤细胞与肿瘤微环境中多种基质成分之间的相互作用。卵巢癌是最致命的妇科恶性肿瘤,以腹膜播散性转移为特征。有证据表明卵巢癌对富含脂肪的大网膜具有特异的转移倾向,大网膜在这个过程中起关键作用,其在腹腔内形成转移性肿瘤微环境促进卵巢癌转移。考虑到卵巢癌转移的独特生物学特性,在富含脂肪的转移性微环境中,卵巢癌细胞与周围基质细胞相互作用的分子机制的阐明,将为晚期卵巢癌患者新的治疗方法的发展提供进一步的见解。在此,我们通过综述在转移性肿瘤微环境中卵巢癌细胞和各种基质细胞之间相互作用机制,以阐明大网膜肿瘤微环境如何协同参与卵巢癌转移的发生发展。

关键词: 卵巢癌, 大网膜, 转移, 肿瘤微环境

Abstract: Tumor metastasis is a complex multi-step process involving the interaction between tumor cells and various matrix components in the tumor microenvironment.Ovarian cancer is the deadliest gynecological malignancy,characterized by disseminated peritoneal metastasis.There is evidence that ovarian cancer has a specific metastatic tendency to the fat-rich omentum.The omentum plays a key role in this process.It forms a metastatic tumor microenvironment in the abdominal cavity to promote ovarian cancer metastasis.Taking into account the unique biological characteristics of ovarian cancer metastasis,the elucidation molecular mechanism of the interaction between ovarian cancer cells and surrounding stromal cells in the fat-rich metastatic microenvironment will provide further insights into new treatment methods for patients with advanced ovarian cancer.Here,this article reviews the interaction mechanism between ovarian cancer cells and various stromal cells in the metastatic tumor microenvironment,and clarifys how fat-rich omentum tumor microenvironment contributes to the occurrence and development of ovarian cancer metastasis.

Key words: Ovarian cancer, Omentum, Metastasis, Tumor microenvironment

中图分类号:

R737.31

董丽娜, 梁田, 张献, 张广美. 卵巢癌对富脂大网膜的器官趋向性转移的研究进展[J]. 实用肿瘤学杂志, 2022, 36(1): 54-58.

DONG Lina, LIANG Tian, ZHANG Xian, ZHANG Guangmei. Research progress on tropism of ovarian cancer to fat-rich omentum organs[J]. Journal of Practical Oncology, 2022, 36(1): 54-58.

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卵巢癌对富脂大网膜的器官趋向性转移的研究进展

Research progress on tropism of ovarian cancer to fat-rich omentum organs

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