心理应激对肿瘤微环境中免疫细胞影响的研究进展

doi:10.11904/j.issn.1002-3070.2021.05.009

摘要/Abstract

摘要： 肿瘤微环境(Tumor microenvironment,TME)在肿瘤的发生发展中发挥重要作用。应激状态下的人体通常会经历一些重要的生物效应,从而损害免疫系统,各种应激反应可以通过调节肿瘤微环境中的免疫细胞,例如自然杀伤细胞、树突状细胞、髓系来源抑制细胞(MDSCs)等,导致肿瘤进展。由于免疫细胞对人体的多项活动都起着重要的调节作用,并且其在肿瘤中的应用也具有十分重要的意义。本文就心理应激如何影响肿瘤微环境中的免疫细胞做一综述,旨在为肿瘤治疗提供新的思路。

关键词: 应激, 肿瘤微环境, 免疫细胞

Abstract: Tumor microenvironment(TME)plays an important role in the occurrence and development of tumors.The human body under stress usually undergoes some important biological effects,which impair the immune system.Various stress responses can regulate immune cells in TME,such as natural killer cells,dendritic cells,and myeloid-derived suppressive cells(MDSCs),etc.the responses lead to tumor progression.Because immune cells play an important role in regulating multiple activities of human body and their application in tumors is also of great significance.This article reviews how psychological stress affects immune cells in TME in order to provide new ideas for tumor therapy.

Key words: Stress, Tumor microenvironment, Immune cells

中图分类号:

R730.3

隆园辉, 陈雪松. 心理应激对肿瘤微环境中免疫细胞影响的研究进展[J]. 实用肿瘤学杂志, 2021, 35(5): 436-440.

LONG Yuanhui, CHEN Xuesong. Research progress on the effect of psychological stress on immune cells in tumor microenvironment[J]. Journal of Practical Oncology, 2021, 35(5): 436-440.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2021.05.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2021/V35/I5/436

参考文献

1 Steinberger KJ,Bailey MT,Gross AC,et al.Stress-induced norepinephrine downregulates CCL2 in macrophages to suppress tumor growth in a model of malignant melanoma[J].Cancer Prev Res(Phila),2020,13(9):747-760.
2 Huang X,He C,Hua X,et al.Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma[J].Clin Transl Med,2020,10(2):e41.
3 Colon-Echevarria CB,Lamboy-Caraballo R,Aquino-Acevedo AN,et al.Neuroendocrine regulation of tumor-associated immune cells[J].Front Oncol,2019,9:1077.
4 Bower JE,Shiao SL,Sullivan P,et al.Prometastatic molecular profiles in breast tumors from socially isolated women[J].JNCI Cancer Spectr,2018,2(3):29.
5 Domblides C,Lartigue L,Faustin B.Metabolic stress in the immune function of T cells,macrophages and dendritic cells[J].Cells,2018,7(7):68.
6 Diwanji N,Bergmann A.Basement membrane damage by ROS-and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue[J].Nat Commun,2020,11(1):3631.
7 Rubio-Patino C,Bossowski JP,Chevet E,et al.Reshaping the immune tumor microenvironment through IRE1 signaling[J].Trends Mol Med,2018,24(7):607-614.
8 Yoo YS,Han HG,Jeon YJ.Unfolded protein response of the endoplasmic reticulum in tumor progression and immunogenicity[J].Oxid Med Cell Longev,2017,2017:2969271.
9 Yao X,Tu Y,Xu Y,et al.Endoplasmic reticulum stress-induced exosomal miR-27a-3p promotes immune escape in breast cancer via regulating PD-L1 expression in macrophages[J].J Cell Mol Med,2020,24(17):9560-9573.
10 He C,Hua W,Liu J,et al.Exosomes derived from endoplasmic reticulum-stressed liver cancer cells enhance the expression of cytokines in macrophages via the STAT3 signaling pathway[J].Oncol Lett,2020,20(1):589-600.
11 He XY,Ng D,Van Aelst L,et al.Stressing out about cancer immunotherapy[J].Cancer Cell,2019,36(5):468-470.
12 Yang H,Xia L,Chen J,et al.Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity[J].Nat Med,2019,25(9):1428-1441.
13 Ma Y,Yang H,Kroemer G.Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies[J].Oncoimmunology,2020,9(1):1673635.
14 Sommershof A,Scheuermann L,Koerner J,et al.Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma[J].Brain Behav Immun,2017,65:140-149.
15 Salvagno C,Cubillos-Ruiz JR.The impact of endoplasmic reticulum stress responses in dendritic cell immunobiology[J].Int Rev Cell Mol Biol,2019,349:153-176.
16 Kumagai Y,Ohzawa H,Miyato H,et al.Surgical stress increases circulating low-density neutrophils which may promote tumor recurrence[J].J Surg Res,2020,246:52-61.
17 Mensurado S,Rei M,Lanca T,et al.Tumor-associated neutrophils suppress pro-tumoral IL-17+ gammadelta T cells through induction of oxidative stress[J].PLoS Biol,2018,16(5):e2004990.
18 Yazdani HO,Roy E,Comerci AJ,et al.Neutrophil extracellular traps drive mitochondrial homeostasis in tumors to augment growth[J].Cancer Res,2019,79(21):5626-5639.
19 Rice CM,Davies LC,Subleski JJ,et al.Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression[J].Nat Commun,2018,9(1):5099.
20 Zhao L,Xu J,Liang F,et al.Effect of chronic psychological stress on liver metastasis of colon cancer in mice[J].PLoS One,2015,10(10):e0139978.
21 Anani W,Shurin MR.Targeting Myeloid-derived suppressor cells in cancer[J].Adv Exp Med Biol,2017,1036:105-128.
22 Ostrand-Rosenberg S,Fenselau C.Myeloid-derived suppressor cells:immune-suppressive cells that impair antitumor immunity and are sculpted by their environment[J].J Immunol,2018,200(2):422-431.
23 Ai L,Mu S,Wang Y,et al.Prognostic role of myeloid-derived suppressor cells in cancers:a systematic review and meta-analysis[J].BMC Cancer,2018,18(1):1220.
24 Ma X,Wang M,Yin T,et al.Myeloid-derived suppressor cells promote metastasis in breast cancer after the stress of operative removal of the primary cancer[J].Front Oncol,2019,9:855.
25 Yan T,Zhang GH,Cheng YZ,et al.Effects of anesthetic technique and surgery on myeloid-derived suppressor cells and prognosis in women who underwent breast cancer surgery:a prospective study[J].Cancer Manag Res,2019,11:5513-5522.
26 Li J,Wang L,Chen X,et al.CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-beta-mTOR-HIF-1 signaling in patients with non-small cell lung cancer[J].Oncoimmunology,2017,6(6):e1320011.
27 Ye L,Wang H,Li H,et al.Eosinophil peroxidase over-expression predicts the clinical outcome of patients with primary lung adenocarcinoma[J].J Cancer,2019,10(4):1032-1038.
28 Antoni MH,Dhabhar FS.The impact of psychosocial stress and stress management on immune responses in patients with cancer[J].Cancer,2019,125(9):1417-1431.
29 Ananth AA,Tai LH,Lansdell C,et al.Surgical stress abrogates pre-existing protective T cell mediated anti-tumor immunity leading to postoperative cancer recurrence[J].PLoS One,2016,11(5):e0155947.
30 Cao Y,Trillo-Tinoco J,Sierra RA,et al.ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression[J].Nat Commun,2019,10(1):1280.
31 Gandhi S,Elkhanany A,Oshi M,et al.Contribution of immune cells to glucocorticoid receptor expression in breast cancer[J].Int J Mol Sci,2020,21(13):4635.
32 Schmidt D,Peterlik D,Reber SO,et al.Induction of suppressor cells and increased tumor growth following chronic psychosocial stress in male mice[J].PLoS One,2016,11(7):e0159059.
33 Shen T,Huang Z,Shi C,et al.Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress[J].FASEB J,2020,34(6):8442-8458.
34 Song M,Sandoval TA,Chae CS,et al.IRE1alpha-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity[J].Nature,2018,562(7727):423-428.
35 Ma Y,Zhang S,Jin Z,et al.Lipid-mediated regulation of the cancer-immune crosstalk[J].Pharmacol Res,2020,161:105131.
36 Jones HP,Aldridge B,Boss-Williams K,et al.A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress[J].J Neuroimmunol,2017,313:99-108.
37 Kobayashi T,Oishi K,Okamura A,et al.Regulatory B1a cells suppress melanoma tumor immunity via IL-10 production and inhibiting T helper type 1 cytokine production in tumor-infiltrating CD8(+)T cells[J].J Invest Dermatol,2019,139(7):1535-1544.
38 Dhabhar FS,Malarkey WB,Neri E,et al.Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields:a tale of three hormones--Curt Richter Award winner[J].Psychoneuroendocrinology,2012,37(9):1345-1368.
39 Canas-Gonzalez B,Fernandez-Nistal A,Ramirez JM,et al.Influence of stress and depression on the immune system in patients evaluated in an anti-aging unit[J].Front Psychol,2020,11:1844.
40 Andersen BL,Goyal NG,Westbrook TD,et al.Trajectories of stress,depressive symptoms,and immunity in cancer survivors:diagnosis to 5 years[J].Clin Cancer Res,2017,23(1):52-61.
41 Zhao Y,Jia Y,Shi T,et al.Depression promotes hepatocellular carcinoma progression through a glucocorticoids mediated up-regulation of PD-1 expression in tumor infiltrating NK cells[J].Carcinogenesis,2019,10:1093.
42 Vulpis E,Soriani A,Cerboni C,et al.Cancer exosomes as conveyors of stress-induced molecules:new players in the modulation of NK cell response[J].Int J Mol Sci,2019,20(3):611.
43 Lazarova M,Wels WS,Steinle A.Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system[J].Expert Opin Biol Ther,2020,2(12):1491-1501.
44 Parihar R,Rivas C,Huynh M,et al.NK cells expressing a chimeric activating receptor eliminate MDSCs and rescue impaired CAR-T cell activity against solid tumors[J].Cancer Immunol Res,2019,7(3):363-375.

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