长链非编码RNA SNHG3在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2021.01.010

摘要/Abstract

摘要： 长链非编码RNA(Long non-coding RNA,lncRNA)是序列长度大于200个核苷酸且不能编码蛋白质的RNA分子。近年来,越来越多的研究指出lncRNA与肿瘤的诊断、预防、治疗及预后有密切联系,在恶性肿瘤的临床应用中有重大价值。小核仁RNA宿主基因3(Small nucleolar RNA host gene-3,SNHG3)可以通过促进细胞增殖、侵袭以及调控上皮-间质转化(EMT)过程来发挥致癌作用,提示其可以作为生物标志物评估肿瘤的恶性程度。本文就近年来SNHG3与恶性肿瘤关系的研究进展做一综述,并探讨通过SNHG3治疗恶性肿瘤的现状和前景。

关键词: 小核仁RNA宿主基因3, 长链非编码RNA, 恶性肿瘤

Abstract: Long non-coding RNA(lncRNA)is a kind of RNA molecule whose sequence length is more than 200 nucleotides and cannot encode a protein.In recent years,more and more studies have pointed out that lncRNA is closely related to the diagnosis,prevention,treatment and prognosis of tumors,and has great value in the clinical application of malignant tumors.Small nucleolar RNA host gene-3(SNHG3)plays a carcinogenic role in promoting cell proliferation,invasion and regulating epithelial-mesenchymal transition(EMT),suggesting that SNHG3 can be used as a biomarker to evaluate the malignancy of tumors.This article reviews the research progress of the relationship between SNHG3 and malignant tumors in recent years,and discusses the current situation and prospects of SNHG3 in the treatment of malignant tumor.

Key words: Small nucleolar RNA host gene-3, Long non-coding RNA, Malignant tumor

中图分类号:

R73-3

郑志远,综述,曲国蕃(审校). 长链非编码RNA SNHG3在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2021, 35(1): 50-54.

ZHENG Zhiyuan,QU Guofan. Research progress of long non-coding RNA SNHG3 in malignant tumor[J]. Journal of Practical Oncology, 2021, 35(1): 50-54.

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