肠道微生物群衍生的代谢产物调控结直肠癌的新进展

doi:10.11904/j.issn.1002-3070.2021.06.012

摘要/Abstract

摘要： 肠道生态系统的改变会影响人类的健康,甚至引发结直肠癌。大量证据表明,在结直肠癌患者的肠道中普遍存在一种病理性微生物群失衡状态,失衡的微生物群衍生的代谢产物也会影响结直肠癌的发生发展。本文综述了由特定肠道微生物群代谢产物触发结直肠癌进程的方式,总结了肠道微生物群代谢产物对结直肠癌贡献的最新进展,并考虑代谢产物的积累效应以及多种代谢产物相结合的方式来预测和预防结直肠癌。

关键词: 肠道微生物群, 结直肠癌, 代谢产物

Abstract: Changes in the intestinal ecosystem will affect human health and even cause colorectal cancer.A large amount of evidence shows that a pathological imbalance of the microbiota is common in the intestines of patients with colorectal cancer,and metabolites derived from imbalanced microbiota can also affect the occurrence and development of colorectal cancer.This article reviews the ways which metabolites of specific gut microbiota trigger the progression of colorectal cancer,summarizes the latest progress in the contribution of metabolites from gut microbiota to colorectal cancer,and considers the accumulative effect of metabolites and the combination of multiple metabolites to predict and prevent colorectal cancer.

Key words: Intestinal microbiota, Colorectal cancer, Metabolites

中图分类号:

R735.3

王朗玥, 赵琦, 吴华星. 肠道微生物群衍生的代谢产物调控结直肠癌的新进展[J]. 实用肿瘤学杂志, 2021, 35(6): 547-551.

WANG Langyue, ZHAO Qi, WU Huaxing. New progress in the regulation of colorectal cancer by metabolites derived from gut microbiota[J]. Journal of Practical Oncology, 2021, 35(6): 547-551.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2021.06.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2021/V35/I6/547

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